巨口鱼科（学名：Stomiidae），是辐鳍鱼纲巨口鱼目的其中一科。

巨口鱼科下分27个属，如下：

Stomiidae is a family of deep-sea ray-finned fish, including the barbeled dragonfishes. They are quite small, usually around 15cm, up to 26cm.