Red blood cells can also clog up the spleen, which can lead to an infarct to the spleen, as well as an enormous backup of blood in the spleen - called splenic sequestration, a life-threatening complication.

镰状细胞也会嵌顿在脾脏，导致脾梗塞及大量血液积存于脾，造成脾隔离危象，会危及生命。