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单词 Somatic recombination
释义

Somatic recombination

英语百科

V(D)J recombination

Simplistic overview of V(D)J recombination of immunoglobulin heavy chains

V(D)J recombination, less commonly known as somatic recombination, is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. The process results in the highly diverse repertoire of antibodies/immunoglobulins (Igs) and T cell receptors (TCRs) found on B cells and T cells, respectively. The process is a defining feature of the adaptive immune system and its development was a key event in the evolution of jawed vertebrates.

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