Separase
![The yeast cohesin complex consists of specialized proteins, including Scc1.[5]](/Images/godic/202502/10/Cohesin_picture23226.png")
![Network diagram with feedback loops to generate switch-like activation of anaphase.[7]](/Images/godic/202502/10/Network_picture3226.png")
![Figure 4: Potential network diagram involving securing and separase to generate switch-like activation of anaphase](/Images/godic/202502/10/Complete_network3227.jpg")
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase. In humans, separin is encoded by the ESPL1 gene.