Ribosomal s6 kinase

![Domain structure of rsk. Numbers refer to amino acid residues of p90 rsk-1 from rat.[6]](/Images/godic/202502/08/Rsk_domains.svg3329.png")
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90 in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.