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单词 Reactive nitrogen species
释义

Reactive nitrogen species

英语百科

Reactive nitrogen species

Reactions leading to generation of Nitric Oxide and Reactive Nitrogen Species. From Novo and Parola, 2008.[1]

Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (·NO) and superoxide (O2) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively. NOS2 is expressed primarily in macrophages after induction by cytokines and microbial products, notably interferon-gamma (IFN-γ) and lipopolysaccharide (LPS).

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