普雷利县（Preiļu rajons、俄语：Прейльский район）是拉脱维亚东南部的一个县。面积2,042平方公里。人口41,479人。县治普雷利。下分2市18村。

Preiļi District (Latvian:Preiļu rajons) was an administrative division of Latvia, located in Latgale region, in the country's east. It bordered the former districts of Jēkabpils, Madona, Rēzekne, Krāslava and Daugavpils.

Districts were eliminated during the administrative-territorial reform in 2009.