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单词 Phosphomannose isomerase
释义

Phosphomannose isomerase

英语百科

Mannose phosphate isomerase

Rough mechanism showing cis-enediol intermediate

Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) (EC5.3.1.8) is an enzyme which facilitates the interconversion of fructose 6-phosphate(F6P) and mannose-6-phosphate(M6P). Mannose-6-Phosphate Isomerase may also enable the synthesis of GDP-mannose in eukaryotic organisms. M6P can be converted to F6P by Mannose-6-Phosphate Isomerase and subsequently utilized in several metabolic pathways including Glycolysis and capsular polysaccharide biosynthesis. PMI is monomeric and metallodependent on Zinc as a cofactor ligand. PMI is inhibited by erythrose 4-phosphate, mannitol 1-phosphate, and to a lesser extent, the alpha anomer of M6P.

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