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单词 Phosphoglycerate kinase deficiency
释义

Phosphoglycerate kinase deficiency

英语百科

Phosphoglycerate kinase

Diagram showing glycolytic and gluconeogenic pathways. Note that phosphoglycerate kinase is used in both directions.



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Phosphoglycerate kinase (EC2.7.2.3) (PGK) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP. Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 1,3-BPG.

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