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单词 Partition constant
释义

Partition constant

英语百科

Partition coefficient

An equilibrium of dissolved substance distributed between a hydrophobic phase (top yellow layer) and a hydrophilic phase (bottom green layer) is established in special glassware such as this separatory funnel that allows shaking and sampling from which the log P is determined.
Drug permeability in brain capillaries (y-axis) as a function of partition coefficient (x-axis).[27]

In the physical sciences, a partition-coefficient (P) or distribution-coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium. Hence these coefficients are a measure of the difference in solubility of the compound in these two phases.

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