Paget's disease of bone

（重定向自Paget disease of bone）

The Ugly Duchess - portrait by Quentin Matsys. Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone.[4]

Micrograph showing Paget's disease of the bone with the characteristic jigsaw puzzle-like/mosaic pattern, H&E stain

Paget's disease of right coxa. Man of 80 years age.

Paget's disease of bone (also termed osteitis deformans or, ambiguously, just Paget's disease; "Paget" is pronounced /ˈpædʒᵻt/) is a chronic disorder that can result in enlarged and misshapen bones. Paget's is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodeling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures and arthritis in the joints near the affected bones. Rarely, it can develop into a primary bone cancer known as Paget's sarcoma. Often Paget's disease is localized to only a few bones in the body. The pelvis, femur, and lower lumbar vertebrae are the most commonly affected bones. Paget's disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body.

单词	Paget disease of bone
释义	Paget disease of bone 英语百科 Paget's disease of bone （重定向自Paget disease of bone） Paget's disease of bone (also termed osteitis deformans or, ambiguously, just Paget's disease; "Paget" is pronounced /ˈpædʒᵻt/) is a chronic disorder that can result in enlarged and misshapen bones. Paget's is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodeling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures and arthritis in the joints near the affected bones. Rarely, it can develop into a primary bone cancer known as Paget's sarcoma. Often Paget's disease is localized to only a few bones in the body. The pelvis, femur, and lower lumbar vertebrae are the most commonly affected bones. Paget's disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body.
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