Nodular lymphocyte predominant Hodgkin's lymphoma
![](/Images/godic/202501/29/Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped3818.jpg")
![Hodgkin lymphoma, nodular lymphocyte predominant (low power view). Notice the nodular architecture and the areas of](/Images/godic/202501/29/Hodgkin_lymphoma,_nodular_lymphocyte_predominant_-_low_power_view_-_H&E_-_by_Gabriel_Caponetti3818.jpg")
![Hodgkin lymphoma, nodular lymphocyte predominant (high power view). Notice the presence of L&H cells, also known as](/Images/godic/202501/29/Hodgkin_lymphoma,_nodular_lymphocyte_predominant_-_high_power_view_-_H&E_-_by_Gabriel_Caponetti3818.jpg")
Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a form of lymphoma.
Some people no longer classified it as a form of classic Hodgkin's lymphoma (HL). This is because the Reed-Sternberg Cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma.