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单词 Neurotropin
释义

Neurotropin

英语百科

Neurotrophin

The dimerization of p75NTR when bound to proneurotrophins and sortilin leads to apoptosis via the JNK cascade.

Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.

They belong to a class of growth factors, secreted proteins that are capable of signaling particular cells to survive, differentiate, or grow. Growth factors such as neurotrophins that promote the survival of neurons are known as neurotrophic factors. Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating programmed cell death - thus allowing the neurons to survive. Neurotrophins also induce differentiation of progenitor cells, to form neurons.

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