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单词 Nalmexone hydrochloride
释义

Nalmexone hydrochloride

英语百科

Nalmexone

Nalmexone synthesis: Lowenstein, M. J.; Fishman, J.; 1967, U.S. Patent 3,320,262

Nalmexone (INN) (code names EN-1620A, UM-592), or nalmexone hydrochloride (USAN), is a semisynthetic, opioid partial agonist or mixed agonist-antagonist with both analgesic and narcotic antagonist properties that was never marketed. In clinical studies it was found to have comparable analgesic efficacy to morphine, though with several-fold reduced potency. In addition, nalmexone's side effects, the most common of which were sleepiness and sweating, were reported to be similar to those of morphine, albeit with a noticeably higher degree of incidence.

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