猪繁殖和呼吸障碍综合征（英语：Porcine Reproductive and Respiratory Syndrome，简称PRRS），俗称蓝耳病（英语：Blue Ear Disease），可导致母猪出现繁殖障碍及仔猪出现严重呼吸道疾病。是一种严重影响经济效益的猪传染病，美国养猪业每年因猪蓝耳病所造成的损失达到六亿美元。

今天，蓝耳病在全球养猪业均呈地方性流行。瑞典、瑞士、新西兰和澳大利亚声称他们并不存在该疾病。

目前中国农业部及一些农业专家认为在中国广泛传播的猪高热病即由蓝耳病病毒（PRRSV）的高致病性病毒株所引起。

Porcine reproductive and respiratory syndrome virus (PRRSV) is a virus that causes a disease of pigs, called porcine reproductive and respiratory syndrome (PRRS), also known as blue-ear pig disease (in Chinese, zhū láněr bìng 猪蓝耳病). This economically important, panzootic disease causes reproductive failure in breeding stock and respiratory tract illness in young pigs. Initially referred to as "mystery swine disease" and "mystery reproductive syndrome," it was first reported in 1987 in North America (2) and Central Europe (3). The disease costs the United States swine industry around $644 million annually, and recent estimates in Europe found that it costs almost 1.5b€ every year.