米特里达梯六世（古希腊语：Μιθριδάτης Ευπάτωρ Διόνυσος，拉丁化：Mithridates Eupator Dionysos；前132年或前131年－前63年）或译为密特里达提六世，是本都王国的一位国王，前121年至前63年在位。他的外号“Ευπάτωρ”的意思是“出身高贵的”，另一个外号“Διόνυσος”则是酒神的名字。米特里达梯六世是罗马共和国末期地中海地区的重要政治人物，也是罗马最著名的敌人之一；他与罗马之间为争夺安纳托利亚而进行的三次战争，历史上称为“米特里达梯战争”。

Mithridates VI or Mithradates VI (; Greek:Μιθραδάτης, Μιθριδάτης), from Old Persian Miθradāta, "gift of Mithra"; 135–63 BC, also known as Mithradates the Great (Megas) and Eupator Dionysius, was king of Pontus and Armenia Minor in northern Anatolia (now Turkey) from about 120–63 BC. Mithridates is remembered as one of the Roman Republic’s most formidable and successful enemies, who engaged three of the prominent generals from the late Roman Republic in the Mithridatic Wars: Lucius Cornelius Sulla, Lucius Licinius Lucullus and Gnaeus Pompey Magnus. He is often considered the greatest ruler of the Kingdom of Pontus.