Melendugno is a town and comune in the Italian province of Lecce in the Apulia region of south-east Italy.

It is known for its marine, which are bathing beaches on the Adriatic Sea: Roca Vecchia, San Foca, Torre dell'Orso and Torre Sant'Andrea, which were awarded the European Blue Flag prize for their calm seas. Melendugno also includes the frazione of Borgagne.