Meglitinide

Meglitinides (glinides) are a class of drugs used treat diabetes type 2.

They bind to an ATP-dependent K (K_ATP) channel on the cell membrane of pancreatic beta cells in a similar manner to sulfonylureas but have a weaker binding affinity and faster dissociation from the SUR1 binding site. This increases the concentration of intracellular potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.

单词	Meglitinide
释义	Meglitinide 英语百科 Meglitinide Meglitinides (glinides) are a class of drugs used treat diabetes type 2. They bind to an ATP-dependent K (K_ATP) channel on the cell membrane of pancreatic beta cells in a similar manner to sulfonylureas but have a weaker binding affinity and faster dissociation from the SUR1 binding site. This increases the concentration of intracellular potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
随便看	daoyin for hemorrhoids daoyin for hepatic syndrome daoyin for hepatopathy daoyin for hernia syndrome daoyin for invigorating renal essence daoyin for lumbago daoyin for muscular numbness daoyin for nasal ulcer daoyin for nephropathy daoyin for nightmare daoyin for oral ulcer daoyin for osteonosus and traumatism daoyin for paralysis daoyin for parasitic disease daoyin for polyuria daoyin for poor appetite caused by gastric disorder daoyin for pulmonary diseases daoyin for pyretic disease daoyin for qi dysuria daoyin for qi stagnation daoyin for regulaing qi daoyin for relieving depression daoyin for seasonal febrile disease daoyin for splenic disease daoyin for splenic syndrome