Lythranidine

Lythranidine is an alkaloid that was first isolated from the plant Lythrum anceps. The compound requires eight steps to synthesize in vitro which requires the formation of a 17 membered ring with a trans-2,6-disubstituted piperidine ring. Lythranidine was first synthesized by Fuji Kaoru, Kohei Ichikawa and Eiichi Fujita in 1971. They were the first paper published on the synthesis of lythranidine. In 1991, a paper was published about the synthesis of lythranidine by William Carruthers , Peter Coggins and John B. Weston who had synthesized the compound in 11 steps using nitrone cycloaddition.