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单词 Apomorphin
释义

Apomorphin

英语百科

Apomorphine

Flow chart depicting the states leading to Alzheimer's disease.  Apomorphine is shown in its role, as proposed by Himeno et al., hindering the progression of the disease.[15]
Conversion of Morphine (I) to Apomorphine (II) in the presence of acid following the example of the morphine skeleton dehydration rearrangement, outlined by Bentley.[24]

Apomorphine (brand names Apokyn, Ixense, Spontane, Uprima) is a non-selective dopamine agonist which activates both D2-like and, to an order of magnitude lesser extent, D1-like receptors. It also acts as an antagonist of 5-HT2 and α-adrenergic receptors with high affinity. The compound is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix. Apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. The apo- prefix relates to it being an aporphine derivative.

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