英特尔国际科技工程大奖赛（Intel International Science and Engineering Fair，简称Intel ISEF）是世界上规模最大的中学生科学竞赛，也是唯一面向9至12年级（即初三至高三）中学生的科学竞赛。素有全球青少年科学竞赛的“世界杯”之美誉，大奖赛亦被称为诺贝尔奖的摇篮，很多位诺贝尔奖得奖者在学生时期都曾参加过这个竞赛，包括2008年诺贝尔化学奖得主钱永健，他也是中国火箭之父钱学森的堂侄。大奖赛得主，更有机会被 「国际天文学联盟」用作命名天上的小行星。

由美国科学与公众社团(Society for Science & the Public)，其前名为科学服务社（Science Service）于1950年创办的美国中学生科学博览会发展而来。美国科学与公众社团是设立在美国华盛顿的一个公益组织，其宗旨是推动科学的发展和技术的进步。作为对支持赞助ISEF的企业回报，科学服务社把竞赛的冠名权授给领衔赞助的企业。1996年，英特尔公司投入巨资成为该竞赛的领衔赞助，并通过一系列的支持活动来推广这一赛事。自1997年开始由英特尔公司赞助。随后的10多年来，英特尔逐步开发、提升了给予学生的奖励，增设教育家论坛（Educator Academy）和与大赛相关的其他活动，使得大赛的影响力和知名度不断扩大。这赛事迄今已有60年的历史。

The Intel International Science and Engineering Fair (ISEF) is the largest pre-college scientific research event in the world, and is owned and administered by the Society for Science & the Public a 501(c)(3) non-profit organization based in Washington, DC. Each May, more than 1500 students from roughly 70 countries and territories arrive to compete in the fair for scholarships, tuition grants, internships, scientific field trips and the grand prizes, including one $75,000 and two $50,000 college scholarships. All prizes together amount to over $4,000,000. Two awards ceremonies are held including: Special Awards Organization Presentation (which now includes the Government Awards Presentations) and the Grand Awards Ceremony. The International Science and Engineering Fair was founded in 1950 by Science Service (now the Society for Science & the Public) and has been sponsored by the Intel Corporation since 1997. As of 2012, seven ISEF alumni went on to win Nobel Prizes, with successful ISEF veterans including Jack Andraka and inventor Alex Deans.