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单词 Ibotenate
释义

Ibotenate

英语百科

Ibotenic acid

Amanita muscaria, which contains ibotenic acid
Activated NMDAR

Ibotenic acid or (S)-2-amino-2-(3-hydroxyisoxazol-5-yl) acetic acid, also referred to as ibotenate, is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere. It is a conformationally-restricted analogue of the neurotransmitter glutamate, and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist. Because of this, ibotenic acid is a powerful neurotoxin, and is employed as a "brain-lesioning agent" in scientific research.

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