羟基苯并三唑
![](/Images/godic/202501/19/HOBT4445.png")
![](/Images/godic/202501/19/HOBT_mechanism_is.svg4445.png")
![Space-filling model of the hydroxybenzotriazole molecule](/Images/godic/202501/19/Hydroxybenzotriazole-3D-spacefill4445.png")
![](/Images/godic/202501/19/Hydroxybenzotriazole_structure.svg4445.png")
羟基苯并三唑（HOBt），白色晶体，苯并三唑的1N-羟基取代衍生物。常用作多肽合成中的外消旋化抑制剂。经典方法用DCC脱水缩合制肽时，由于DCC活性很高，常使底物的手性中心无法在产物中很好地保持。一般加入羟基苯并三唑等助剂以降低活化酯的活性，从而抑制外消旋化。详见多肽合成一文。
羟基苯并三唑通常都是以单水合物结晶（~11.7%水，重）出售的。无水羟基苯并三唑有爆炸性，使用时需注意。
Hydroxybenzotriazole
中文百科
英语百科
Hydroxybenzotriazole 羟基苯并三唑
![Hydroxybenzotriazole](/Images/godic/202501/19/HOBT4446.png")
![](/Images/godic/202501/19/HOBT_mechanism_is.svg4447.png")
Hydroxybenzotriazole (abbreviated HOBt) is an organic compound that is a derivative of benzotriazole. It is a white crystalline powder, which as a commercial product contains some water (~11.7% wt as the HOBt monohydrate crystal). Anhydrous HOBt is explosive.
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