Cerulenin

Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. These two behaviors may increase the availability of energy in the form of ATP, perhaps sensed by AMPK, in the hypothalamus.

单词	Helicocerin
释义	Helicocerin 英语百科 Cerulenin Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. These two behaviors may increase the availability of energy in the form of ATP, perhaps sensed by AMPK, in the hypothalamus.
随便看	disymmetric cephalothoracopagus disymmetric dispersion disymmetric face disymmetric ischiopagus disymmetric of interference colors disymmetry disymmetry constant disymmetry of interference colors disyn disynaptic Disyncran disyndiotactic disyndiotactic polymer di syndiotactic polymer disyndiotatic structure Disynformon disyntheme Disyntramine disyoke Disyston Di Syston Disyston sulphoxide Disāng R. Disūq dit

Helicocerin

Cerulenin