Huntingtin-associated protein 1

（重定向自HAP1）

Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. This protein was found to bind to the mutant huntingtin protein (mHtt) in proportion to the number of glutamines present in the glutamine repeat region.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate (HGS). The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport.

单词	HAP1
释义	HAP1 原声例句柯南脱口秀 But they just stopped at the hap part. 但他们就停在“祝”字上。摩登家庭第四季_Modern Family-Season04 " What's the haps tonight" ? Nobody says that. " 今夜漫漫如何消遣" 没人会这么说的。我们这一天第一季 Okay, what is hap...What is happening? 好吧，发生了...发生了什么？史蒂夫·哈维励志演讲 There are no just haps in life. 生活中没有偶然。大森林里的小木屋 When Pa came back, he told what had hap- pened. 爸爸回来后，他告诉了发生的事情。水孩子 Come wi' me, and I'll hap thee up somewhere. 跟我来，我会把你带到某个地方。草原上的小木屋 She did so want to see what was hap- pening. 她确实想看看发生了什么意外。四季随笔 At any moment I might have been driven forth by evil hap, by nagging necessity. 在任何时候，我都可能被邪恶的运气，被唠叨的需要驱赶出去。人与鬼（上） " Happen? What was sure to hap — " ? Mr. Grew's question wavered on his lip and passed into a tremulous laugh. " Is it something I've done that you don't approve of? Is it — is it the Buckle you're ashamed of, Ronald Grew" ? “发生了什么？肯定会发生什么——”？格鲁先生的问题在他的嘴唇上摇摆不定，变成了颤抖的笑声。 “这是我所做的你不赞成的事情吗？是——是你感到羞耻的 Buckle，Ronald Grew”？英语百科 Huntingtin-associated protein 1 （重定向自HAP1） Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. This protein was found to bind to the mutant huntingtin protein (mHtt) in proportion to the number of glutamines present in the glutamine repeat region. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate (HGS). The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport.
随便看	bill of law bill of loading Bill of Material bill of material processor Bill of materials bill of meterials bill of mortality bill of oblivion Bill of Pains and Penalties bill of parcels bill of particulars bill of payable bill of payment Bill of Peace bill of pratique bill of privilege bill of prosecution bill of purchasing Bill of quantities bill of quantities, BOQ bill of quantity bill of qulity bill of receivalbe bill of remittance Bill of Resources