顾恺之（约348年－405年），字长康，晋陵无锡（今江苏无锡）人，是中国东晋时代的画家、官员。

出生年份没有记载。约364年在南京为石棺寺画维摩诘像，引起轰动。366年当上大司马参军，392年为殷仲堪参军，405年升为散骑常侍。

顾恺之多才，工诗赋，善书法，被时人称为“才绝、画绝、痴绝”，他的画线条连绵流畅，如“春蚕吐丝”。着有《论画》、《魏晋胜流画赞 (摹搨妙法)》和《画云台山记》三本绘画理论书籍(以上三篇文章现今存在最早版本由唐张彦远历代名画记抄录以传)，提出“以形写神”、“尽在阿堵中”的传神理论。其与曹不兴、陆探微、张僧繇合称“六朝四大家”。

Gu Kaizhi (simplified Chinese:顾恺之; traditional Chinese:顧愷之; pinyin:Gù Kǎizhī; Wade–Giles:Ku K'ai-chih; c. 344–406), courtesy name Changkang (長康), was a celebrated painter of ancient China. He was born in Wuxi and first painted at Nanjing in 364. In 366, he became an officer (Da Sima Canjun, 大司馬參軍). Later he was promoted to royal officer (Sanji Changshi, 散騎常侍). He was also a talented poet and calligrapher. He wrote three books about painting theory: On Painting (畫論), Introduction of Famous Paintings of Wei and Jin Dynasties (魏晉勝流畫贊) and Painting Yuntai Mountain (畫雲台山記). He wrote: "In figure paintings the clothes and the appearances were not very important. The eyes were the spirit and the decisive factor."