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单词 Glycosome
释义

Glycosome

英语百科

Glycosome

Glycosomes in the trypanosomatid
By taking advantage of the pores in the membrane of the glycosome, a drug can enter the organelle and be used to kill the trypanosoma brucei

The glycosome is a membrane-enclosed organelle that contains the glycolytic enzymes. The term was first used by Scott and Still in 1968 after they realized that the glycogen in the cell was not static but rather a dynamic molecule. It is found in a few species of protozoa including the Kinetoplastida which included the suborders Trypanosomatina and Bodonina, most notably in the human pathogenic trypanosomes, which can cause sleeping sickness and Chagas's disease, and leishmaniasis. The organelle is bounded by a single membrane and contains a dense proteinaceous matrix. It is believed to have evolved from the peroxisome. This has been verified by work done on Leishmania genetics.

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