AMG133 activates receptors for GLP-1 while blocking receptors of glucose-dependent insulinotropic polypeptide (GIP), a hormone secreted in the small intestine in response to food intake that stimulates the production of both insulin and glucagon.

AMG133 激活 GLP-1 受体， 同时阻断葡萄糖依赖性胰岛素促泌多肽 (GIP) 受体，GIP 是一种在小肠中响应食物摄入而分泌的激素， 可刺激胰岛素和胰高血糖素的产生。