弗莱河是巴布亚新几内亚的河流，由西部省负责管辖，河道全长1,050公里，流域面积约76,000平方公里，最终注入巴布亚湾，支流有斯特里克兰河和奥克泰迪河。

弗莱河中上游有一段是巴布亚新几内亚及印尼巴布亚省的界河，而这一段也是巴布亚新几内亚唯一位于东经141度以西的领土。

The Fly at 1,050 kilometres (650 mi), is the second longest river in Papua New Guinea, after the Sepik. The Fly is the largest river in Oceania, the largest in the world without a single dam in its catchment, and overall ranks as the 25th-largest river in the world by volume of discharge. It rises in the Victor Emanuel Range arm of the Star Mountains, and crosses the south-western lowlands before flowing into the Gulf of Papua in a large delta.