Enhanceosome
![Structural model of the enhanceosome. Double-stranded DNA is shown in green and pink; the ATF-2/c-Jun coiled-coil DNA binding domain is shown in purple; interferon response factors are shown in beige; and NF kappa B is shown in orange (p105 subunit) and blue (p65 subunit).](/Images/godic/202501/11/Enhanceosome_vertical2047.png")
The enhanceosome is a higher-order protein complex assembled at the enhancer and regulates expression of a target gene. The binding and assembly of the activating proteins is cooperative due to energetically favorable protein-protein interactions formed in the complex.