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单词 Endostatins
释义

Endostatins

英语百科

Endostatin

(重定向自Endostatins)
Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).

Endostatin is a naturally-occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.

Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).

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