AlkB

AlkB protein is a protein induced during an adaptive response and is involved in the direct reversal of alkylation damage. AlkB specifically removes alkylation damage to single stranded (SS) DNA caused by S_N2 type of chemical agents. It efficiently removes methyl groups from 1-methyl adenines, 3-methyl cytosines in SS DNA. AlkB belongs to the Fe (II)/2-oxoglutarate-dependent dioxygenase superfamily and oxidatively demethylates the DNA substrate. Demethylation by AlkB is accompanied with release of CO₂, succinate and formaldehyde.

单词	AlkB
释义	AlkB 英语百科 AlkB AlkB protein is a protein induced during an adaptive response and is involved in the direct reversal of alkylation damage. AlkB specifically removes alkylation damage to single stranded (SS) DNA caused by S_N2 type of chemical agents. It efficiently removes methyl groups from 1-methyl adenines, 3-methyl cytosines in SS DNA. AlkB belongs to the Fe (II)/2-oxoglutarate-dependent dioxygenase superfamily and oxidatively demethylates the DNA substrate. Demethylation by AlkB is accompanied with release of CO₂, succinate and formaldehyde.
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