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单词 Abortive transcription
释义

Abortive transcription

英语百科

Abortive initiation

Abortive cycling by T7 RNA polymerase
DNA scrunching mechanism. During initial transcription, RNA polymerase (RNAP) remains stationary on the promoter and unwinds and reels in downstream DNA.

Abortive initiation, also known as abortive transcription, is an early process of genetic transcription in which RNA polymerase binds to a DNA promoter and enters into cycles of synthesis of short mRNA transcripts which are released before the transcription complex leaves the promoter. This process occurs in both eukaryotes and prokaryotes. Abortive initiation is typically studied in the T3 and T7 RNA polymerases in bacteriophages, and in E. coli.

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