MiceimmunizedwithpCTLA 2 - HEVE 2 producedhighlevelsof specificanti - HEVE 2 totalIgGtiterswithIgG 2 a , IgG 2 band IgG 1 subclassespredominantintheserum, approximately 50 - to 100 - foldhigherthanthoseinmiceimmunizedwithpHEVE 2, whoseserumcontainedpredominantlyIgG 1. Conclusion CTLA 4 - HEVE 2 chimericvaccinestimulatesstrongimmunere - sponses inmice, makingitpossibleforfurtherexplorationintochimericDNAvaccinesthattargettheantigento APCs.

pCTLA4 -HEVE2诱导高水平的IgG2a 、 IgG2bTh1型抗体和IgG1Th2型抗体应答, pHEVE2则以IgG1Th2型抗体应答为主. 结论CTLA4-HEVE2嵌合DNA疫苗 有效地增强动物对 HEVE2 抗原的免疫应答, 为进一步研究抗原靶向性的嵌合DNA疫苗奠定基础.

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