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大小写变形:topotecan hydrochloride
Aim To improve the preparation process of topotecan hydrochloride.
目的改进盐酸拓扑替康的合成方法.
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Method Topotecan hydrochloride was synthesized from camptothecin by improved hydrogenation oxidation and the Mannich reaction.
方法以天然产物喜树碱为原料,经氢化还原、化制得中间体10羟基喜树碱,再与双(甲氨基)烷反应制备盐酸拓扑替康.
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