AimTo synthesize ribonucleoside - incorporated oligonucleotides and investigate their binding abilities with complementary sequences.

目的合成异核苷掺入寡核苷酸并考察它们与互补序列的结合能力.

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Objective To study antiviral effect of Lihposome - mediated antisense oligonucleotides COS - ASIN.

目的　研究脂质体介导的反义寡核苷酸在体外对乙型肝炎病毒基因复制和表达的抑制.

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Until now, several methods have been developed to improve the intracellular delivery of antisense oligonucleotides.

到目前为止, 已发展了数种提高寡聚核苷酸类化合物细胞内转运的方法.

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However, many classes of oligonucleotides are polyanions, so they cannot cross over cell membrane.

但是, 大多数此类化合物是呈负电性的, 不能有效跨越细胞膜.

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Using the computational approach, we studied the oligonucleotides repeats in current available bacterial whole genomes.

用计算生物学方法, 我们对已测序的细菌完全基因组中的寡核苷酸重复序列作了详细研究.

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Antisense oligonucleotides have been successfully employed to inhibit and modulate specifically gene expression.

反义寡聚核苷酸已成功用于对基因表达的特异性调控与抑制.

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Telomerase is a specialized reverse transcriptase single - stranded chromosome ends and oligonucleotides in vivo and in vitro.

端粒酶是一种特殊的逆转录酶,它能在体内延伸染色体 单链 末端,在体外延伸寡聚核苷酸.

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