Cyclin - cdk compound is composed of Cyclin and cdk different cell cycle.

多种肿瘤存在着Cyclin的异常表达,cdk的激活及其抑制因子的丢失.

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CDK activation by cyclin binding.

1)CDKs结合cyclin后活化.

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Rapamycin arrested cell cycle in G 1 phase to antitumor by degrading the CDK - cyclin complexes kinase activity.

Rapamycin还能通过降低CDK-cyclin复合物激酶的活性,使细胞周期阻滞在G1期,从而发挥抗肿瘤的作用.

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Cell cycle is mainly regulated by cyclin, cyclin dependent kinase ( CDK ) and cyclin dependentkinase inhibitor ( CDKI ).

细胞周期主要是由细胞周期蛋白 ( cyclin), 细胞周期蛋白依赖性激酶 ( CDKs ) 和CDK抑制蛋白(CDKI ) 来调控的.

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Objective To construct recombinant expressing Cyclin D 1 and CDK 4 proteins.

[目的]建表达人细胞周期蛋白D1及细胞周期蛋白激酶CDK4融合蛋白的重组体.

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Cell cycle in plants is controlled byactivity of cyclin - dependent kinase ( CDK ) complexes.

植物细胞周期主要由细胞周期蛋白依赖性激酶 ( CDK ) 复合物调控.

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Cyclin D 1 and CDK 4 proteins were expressed correctly in insect cells and had their biological activity.

成功构建了细胞周期蛋白D1及CDK4真核杆状病毒表达载体,并且在昆虫细胞中正确表达了具有生物活性的细胞周期蛋白D1及CDK4融合蛋白.

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Protein serine theronine phosphatase inhibitor or cyclin dependent kinase ( CDK ) inhibitors could abolish the enhancement.

而蛋白丝氨酸苏氨酸磷酸酯酶抑制剂以及细胞周期蛋白依赖性激酶 ( dk ) 制剂可阻断该凋亡敏感性增强效应.

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CDK and cyclin are key molecules that control and coordinate DNA - synthesis, chromosome separation and cell division.

CDK和细胞周期蛋白是控制和协调DNA合成 、 染色体分离和细胞分裂的重要分子.

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Effects on the protein expression of cyclin A , B _ 1 and D _ 1 were assessed by Western Blot.

Western印迹检测细胞周期蛋白D1 、 A和B1表达的变化.

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The expression of cyclin D 1 and CDK 4 were detected by RT PCR method.

RTPCR检测细胞周期素D1(cyclinD1)、细胞周期蛋白依赖激酶4(CDK4)mRNA的表达.

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Conclusions : Overexpression of cyclin D 1 and CDK 4 may involve in the onco - pathogenesis of ESC.

我们在相应的癌旁组织中亦发现cyclinD1和CDK4的过表达.

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Objective: To investigate the expressions of cyclin E, CDK 2, and Ki - 67 and their clinical significance in leukemia.

的: 探讨白血病细胞周期素E(cyclinE) 、 细胞周期蛋白依赖性激酶2(CDK2)、细胞增殖相关抗原(Ki67)在白血病中的表达及其临床意义.

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