gene expression

The gene-expression profile of aggressive cutaneous and uveal melanoma cells resembles that of an undifferentiated, embryonic-like cell.

One of the major challenges in molecular biology is to understand the precise mechanism by which gene expression is regulated.

It is possible to understand gene expression in sexual cells with the help of newtechnologies and methods.

How transcription factors regulate gene transcription on chromatin is the central question of the study of gene expression regulation.

To assess gene expression in each small bit of tissue, researchers expose its RNA to a gene chip, or DNA microarray.

The effects of steroids that are mediated by the modulation of gene expression are known to occur with a time lag of hours or even days.

Presently, retroviral vector was extensively used for gene therapy, exogenous gene expression and genetically engineering vaccine.

One of the greatest challenges facing modern molecular biology is the understanding of the complex mechanisms regulating gene expression.

With epigenetic drugs, it is possible to reverse aberrant gene expression profiles associated with different disease states.

This is the only example we know of where it is possible to image activated endogenous gene expression without having to transfect cells.

CONCLUSION: The methods introduced apply very generally, to any similarity matrix describing gene expression.

Such images provide an important anatomical reference on which researchers can overlay information about gene expression.

Each tissue ribbon is then dropped into a test tube and its RNA purified for gene expression analysis.

abstract: Epigenetics is defined as the investigation of heritable changes in gene expression that occurs without a change in DNA sequence.

Then we discuss how the gene expression matrix can be used to predict putative regulatory signals in the genome sequences.

However, these iPS cells had a different global gene expression pattern from ES cells and failed to produce adult chimeric mice.

Changes in gene expression do not necessarily affect health, because the body's homeostatic mechanisms may compensate.

By measuring brain activity, Kinsley tracked these variations through a variety of techniques including differences in gene expression.

One of the roles of this protein is to enter the cell nucleus and activate gene expression.

When the density of this molecule rise to a certain degree, specialized gene expression of the bacterial changed.

Fusion to a reporter gene therefore allows the factors controlling gene expression to be identified.

BACKGROUND: The use of global gene expression profiling is a well established approach to understand biological processes.

Gene expression in plants can be suppressed in a sequence-specific manner by infection with virus vectors carrying fragments of host genes.

This study also can be referred as a reference to plant resistance mechanisms and gene expression research of other cereal crops.

The first was to establish changes in gene expression along the epididymis as androgenic support is withdrawn.

These chemical changes are now thought to include gene expression, not just suppression, as had been previously hypothesized.

These data suggest that regulation of gene expression by antisense and double-stranded RNAs could be a common phenomenon in mammalian cells.

Simple molecular mechanisms, such as tissue-restricted gene expression, seem to explain these associations only in rare cases.

Perturbations of these gene products are combined with dynamic, global analyses of gene expression.

He noted that 16 of these papers stated that the underlying 'gene expression' data for the studies were publicly available.

As a late-branching eukaryote, G. lamblia may have special mechanisms for regulating gene expression which differ from other eukaryotes.

We therefore named this RNA molecule that was able to toggle gene expression from on to off a "riboswitch. "

One of the best known epigenetic factors is DNA methylation, which is a major mechanism for regulation of gene expression.

Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA.

We also found positive correlated up regulation in the gene expression in A and its receptor in cardiovascular system.

Older 16-month-old mice were given the same tasks and did not exhibit the same gene expression.

Also, new tools that are available to manipulate gene expression, and genes of interest in specific regions of the brain, will be presented.

The process to identify such biosignatures is called gene expression profiling, and it's done using microarray analysis.

Studies on mechanism of various diseases could be deepened with the progressing of differential gene expression analysis technique.

Prokaryotic expression system was used to build several important Vibrio parahaemolyticus virulence-related gene expression vector.

High-throughput gene expression screens provide a quantitative picture of the average expression signature of biological samples.

Our paper investigates two important problems of bioinformatics: gene expression data clustering analysis and structural database searching.

This tool offers a user-friendly interface, and is completely integrated within the Gene Expression Pattern Analysis Suite (GEPAS).

The transgenic efficiency and precise control of gene expression are the key limiting factors on preparation of transgenic animals.

Species, cultivar and organ specificity of freezing induction and its relation to protein synthesis and gene expression.

Serial analysis of gene expression technique is a new method of qualitative and quantitative study of gene expression.

These compounds act in a variety of ways to inhibit gene expression and DNA replication and also alter nuclear architecture.

Analysis of differential gene expression can contribute to understanding of the possible mechanisms of diabetic gangrene.

Assessing whether different biological populations have gene expression profiles that correlate to their biogeographical distribution.

The invention relates to a chimeric promoter construct useful for neuronal cell specific gene expression.

Gene mutations on BCP in alcoholics may be the mechanism of leading to consistent HBV infection replication and gene expression.

MOTIVATION: Post-translational modifications to histones have several well known associations with regulation of gene expression.

However, the analysis of spatial gene expression patterns with single-cell resolution requires quantitative in situ measurement techniques.

Objective To investigate gene expression patterns of atherosclerosis (As) induced by intermittent hypoxia and hyperlipemia.

Gene-expression profiles of tumor tissue failed to yield a significant association with survival.

The AC-rich motif, Pal-box, is an important cis-acting element for gene expression involved in phenylpropanoid biosynthesis.

Putatively in agreement with murine data, no MBL gene expression could be detected in advanced human atherosclerotic lesions.

This domain relocates to the nucleus, where it combines with the transcription factor Suppressor of Hairless to regulate gene expression.

However, recent advances indicate that efficient, long-term gene expression can be achieved by non-viral means.

In inflammation responses, differentiation of T helper cells and gene expression of cytokine and chemokine are all regulated by epigenetics.

Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression.

In this study, we investigate the relationship between the tissue-specificity of gene expression and the type of protein encoded.

Now we're also about to publish a study -- a study showing you can change gene expression in men with prostate cancer.

These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.

Pichia pastoris as an excellent heterologous gene expression system has been widely used in the production of phytase.

Epigenetics is the study of heritable changes in gene expression that occurs without a change in DNA sequence.

DNA methylation plays an important role in gene expression regulation during biological development and tissue differentiation in plants.

Recent molecular genetics studies have revealed a genetic network that enables the critical daylength response of florigen gene expression.

MOTIVATION: Gene expression microarray experiments can generate data sets with multiple missing expression values.

Conclusions Environmental modulation of gene expression and pathogenesis inY. pestis, especially the island.

Suspension cultures maintained for long periods may alter in properties due to mutation and altered gene expression.

Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL.

Our results indicate that differences of gene expression between hybrids and their parents are very obvious.

Reducing gene expression turns down the activity of a gene .

A. plots, and helpful to understand to gene expression.

The differentiation degree of squamous cell carcinoma is not relative to the FAS gene expression.

Mechanical stress plays an important role in the cell proliferation, differentiation, apoptosis, gene expression and tissue growth.

The experimental results show that the proposed approach can improve the cluster results of cancer gene expression profile.

Down-regulation of MAL gene expression is of frequent occurrence in human esophageal cancer.

Quorum-sensing is a physiologic accommodation of bacterial in gene expression according to its quorum.

Recent genome and proteomic analyses of visceral fat from PCOS patients have detected aberrance in gene expression and protein composition.

Some researches of the concentration of lactoferrin in milk and the gene expression regulating mechanism were reviewed in this paper.

Since its invention, SAGE has been widely applied to analyzing gene expression in many biological and medical studies.

Without the correct information making its way into the nucleus, gene expression is altered, often with dire consequences.

For instance, if human artificially block a gene expression in pollen development, male sterility may be caused.

Finally, we provided in vivo validation of the in vitro findings by analyzing gene expression data from individuals with FTD.

The strange arrows with flat heads are a notation used in the literature of gene expression and gene regulation, and they mean "inhibits" .

As a result of gene expression assays, there is growing recognition that breast cancer is a molecularly heterogeneous disease.

Serial analysis of gene expression (SAGE) is a method for identifying and quantifying transcripts from eukaryotic genomes.

Finally, in mammals, cohesin co localizes with the CTCF insulator protein and controls gene expression in a CTCFdependent manner.

The vast majority of the genes identified to date in the process encode transcription factors involved in the regulation of gene expression.

Gene expression regulation is a multilevel complex process, transcriptional level regulation is the most critical link.

Since it contains large amount of gene expression information, it becomes the first choice for screening novel genes in most laboratories.

But what if we intervene on behalf of gene expression by controlling the formation and liberation of free radicals in the body?

Aim To investigate the effects of gene expression through activating endothelial target for acetylcholine ( ETA).

We attempted to identify alterations in gene expression underlying the abnormalities in the blood cells of narcoleptic patients.

Except for one area of gene expression control, plant research has significantly fallen behind studies in insects and vertebrates.

This chapter describes methods for learning gene interaction networks from high-throughput gene expression data sets.

Once an image enters the database, an algorithm converts the image to a "heat map" of gene expression.

This gene regulation is accomplished by epigenetic processes that control gene expression without altering DNA.

This gene expression program leads to changes in both cellular morphological and physiological phenotypes.

Objective To explore the relevance between MAL gene expression, clinical stage and histologic grade of esophagus cancer.

BACKGROUND: DNA Microarrays have become the standard method for large scale analyses of gene expression and epigenomics.

Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale.

Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear.

Whole-mount in situ hybridization can accurately reflect the virus integration sites and target gene expression levels.

Transcription factors are proteins that bind specifically to defined DNA sequences to promote gene expression.

Rigorous studies in people are needed to confirm that changing gene expression in older skin to match younger skin improves skin quality.

Starch mycose synthetase, its coding gene, expression and engineering bacterium are disclosed.

Conclusion: We suggested that highly efficient gene expression systems and receptor cells. . .

One of their main uses is to measure gene expression.

We have studied the gene expression of ribonuclease inhibitor (RI) by using high performance capillary electrophoresis(HPCE).

Professor Liu researches on the regulation of gene expression and biological medicine engineering.

Gene-expression arrays have generated molecular predictors of relapse and drug sensitivity in breast cancer.

DNA methylation contributes to the control of gene expression and plays an essential role in cellular physiology.

Results There were obvious differences in gene expression between human lung cancer cells before and after ATRA treatment.

Conclusion: Biological active substance from Hp regulates gene expression through SRE cis-element.

Researchers are aware that cells on flat surfaces have skewed metabolisms, gene expression and growing patterns.

Even this short, relatively mild food reduction resulted in long-term changes in gene expression, the researchers found.

In mammalian cells, the promoter is a complex region containing binding sites for many proteins that regulate gene expression.

To confirm the role of exercise on gene expression in muscle, the scientists then studied how calcium affected the entire system.

Immune response gene expression and impairment of alveolar growth were studied in exposed vs. controlled mice.

It requires controlled plasmid delivery systems and tissue specific gene expression system.

Cell identity and differentiation are determined by patterns of regulatory gene expression.

Stress response involves modulation of enzymatic activities and changes in gene expression.

Objective The gene expression was studied to investigate the molecular mechanism of heat acclimation.

One adds molecules called methyl groups to the DNA of the gene. This suppresses gene expression.

Conersely, in other regions such as the hippocampus and olfactory bulb, which is associated with smell, gene expression was more contained.

Plant promoters are important cis-regulatory elements for regulating gene expression.

The histological changes occur later, which is the result of early gene expression.

Gene expression of vascular endothelial growth factor increased in the cell-administrated group.

Activation of SAR requires the hormone salicylic acid (SA), which induces SA-responsive gene expression.

NS2 protein as a non-structural protein mainly involved in viral DNA replication and regulation of gene expression.

DNA array technology is a technique for studying gene expression by comparing samples of different genes.

The analysis of BLAST alignment showed that the interference fragment could specially inhibit SSIII gene expression.

Previous studies had found age-related changes in gene expression in the hippocampus, a crucial memory center in the brain.

Histone lysine methylation plays a key role in the organization of chromatin structure and the regulation of gene expression.

AIM: To investigate the gene expression of proteins handling the calcium homeostasis in diabetic rat heart.

The output lists all available information including the relative gene expression level.

HDAC activity plays a key role in the regulation of gene expression, and HDAC is a clinically validated cancer target.

A gene expression programming algorithm embedded with estimation of distribution algorithms, LPGEP, is proposed here.

Objective To investigate the change of gene expression in human transitional cell carcinoma(TCC).

Gene expression profiling showed that tubulocystic carcinoma displayed a unique molecular signature.

There were also significant similarities between iPSCs and cells of origin in factors related to the epigenetic control of gene expression.

Investigation of Gene Expression Profile in Normal Gallbladder Tissue .

From these results it can be concluded that the symbiotic Chlorella probably effect the gene expression of the host cell.

They also recorded gene expression in real-time using a bioluminescent reporter of gene activity.

(The epigenome governs patterns of gene expression. ) This reprogramming could explain how we are indeed evolving so fast.

So they did a postmortem analysis of gene expression in the brains of smokers, alcoholics and those who had done both during their lives.

Gene chip is a research tool on molecular biology which can detect generous gene expression rapidly.

Following-up laboratory study for erythrocyte CR-1 quantity gene expression and activity in five patients with acute radiation sickness.

Using this improved method, we analyzed the gene expression patterns of H and SP, achieving 13 differentially expressed cDNA fragments.

The elongation gene expression of developing cotton fiber cultured in field and in vitro was detected by using relative quantitative RT-PCR.

The researchers also found that osteopontin gene expression triggered the expression of profibrogenic genes.

Gene therapy by modification of gene expression will treat cerebral infarction.

Spira says he has also found gene expression differences in a study using healthy former smokers.

Scientists say that mass bee deaths may be caused by viruses that disrupt gene expression.

Therefore, Bacillus subtilis was selected as xylanase gene expression host in this study.

This paper, from the cholesterol stone and liver gene expression relations are reviewed in this paper.

Regulation of foreign gene expression in plastids is influenced by various factors.

Chronic high palmitate results in down regulation of PKB threonine phosphorylation and insulin gene expression in HIT-T15 Cells.

"Distinct Types of Diffuse Large B Cell Lymphoma Identified by Gene Expression Profiling. " Nature (2000).

These results illustrate the importance of examining virulence gene expression in the context of bona fide host-pathogen interactions.

Conelustion Y. pestis , through its life cycles , how adaptive gene expression fosters pathogenesis.

It focuses on the proteins that control plant gene expression at the chromatin level.

in addition , gene expression patterns across brain regions show variable degrees of restriction to single brain structures.

Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo.

Gene expression microarrays hold great promise for studies of human disease states.

Undesired immune responses limit duration of gene expression.

CONCLUSIONS: We developed a composite prognostic model for HCC recurrence, based on gene expression patterns in tumor and adjacent tissues.

yet, the molecular mechanisms that temporally pattern gene expression remain largely unknown.

Objective To research and to locate the gene expression of the cysteine protease in Pagumogonimus skrjabini.

Superpure DNA can be prepared using RNA transcribed from DNA in the course of gene expression.

Tissue specific promoter can control gene expression in certain organ or tissue.

A "transcription profile" or "gene expression profile" is a measure of how well a person's mitochondria are working.

The study was the first to examine the gene expression profile, or the molecular "fingerprint" , of aging in healthy disease-free humans.

Expression of muscle myosin heavy chain-1 gene decreased and muscle ubiquitin gene expression increased in sepsis.

But the gene expression paradigm is widely accepted among geneticists.

Ph. D graduate research on regulation of plastid gene expression in higher plant.

We mainly investigated the regulatory effects of the estrogen receptor and retinoic acid receptor on the CRH gene expression. 1 .

Left ventricular (LV) geometry, hemodynamics, and cardiac gene expression were evaluated on day 28.

The higher gene expression of IGFBP-6 may be induced the developmental skeleton defect in CCF rat.

It is main research work on pathogenic mechanism to explore gene expression after entomopathogenic fungi invade into insect body.

Li ZJ, Li YP, Gai HR, et al. Research of gene expression profile of liver tissue in rat sepsis model.

Gene expression in eukaryotes is regulated primarily at the level of transcription.

Objective: To develop and optimize the Salmonella enterica serovar Typhi genomic DNA microarray based gene expression profiling.

These data show the feasibility of aspiration biopsy for intragraft monitoring of gene expression.

These results suggest that IRO2 is involved in the regulation of gene expression under Fe-deficient conditions.

According to early results of computer simulation predicted that the vaccine will be mounted on HIV gene expression than the natural better.

There are lots of cluster methods applied to the analysis of gene expression data.

Multi-scale theory analysis of gene expression is a new and effective bioinformatics method, which is worth furth. . .

Methods The MAL gene expression in 45 cancer patients was detected with RT-PCR and semi-quantitative RT-PCR technique.

"They use these bacteriophytochromes to control gene expression, " Shu says.

We discussed the relation between level of LIF gene expression and embryonic implantation.

One model is fuzzy cluster analysis of gene expression data based on a cluster validity measure named Xie-Beni index.

To facilitate the study of iron-regulated gene expression in Bordetella pertussis, we cloned the fur gene from this organism.

The results are as follows: Exogenous hormones enhance HFT gene expression.

Results: Compared with normal person, the RIZ1 gene expression level decreased significantly in acute myeloid leukemia(P05).

To explore the correlation of adenine nucleotide translocator 3 (ANT3) gene expression level with primary biliary cirrhosis.

Objective To investigate the relationship of atherosclerosis and vascular cell adhesion molecule-1 (VCAM-1) gene expression.

This is the branch of genetics that looks at how the environment influences gene expression.

But because the DNA code itself remained unchanged, Morris's team suggest that the changes in gene expression are epigenetic.

In 2001 Merck acquired Rosetta Inpharmatics, a software firm specialising in the interpretation of gene-expression profiles.

As a drug carrier, it can protect DNA, and enhance time of gene expression.

Another application could be to create models for human diseases, for many of them are caused by a disorder of gene expression.

A imputation method based on Mahalanobis distance was proposed to estimate missing values in the gene expression data.

The 20 different sequences they chose covered the range from minimum to maximum gene expression.

Several classification methods based on DNA gene expression microarray data are introduced in this paper.

A large number of studies have shown that gene expression is effected each other.

Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.

CONCLUSION: Aldosterone inhibits the gene expression and protein secretion of visfatin in 3T3-L1 adipocytes.

Here, we studied the regulation of HPO gene expression.

Gene expression under high pressure.

Recent data link changes in gene expression to chromatin remodeling, such as histone modifications and histone replacement.

THE EFFECT OF EXCESS IODINE CAUSED BY SUPPLYING IODINE DURING GESTATION ON BRAIN APOPTOSIS AND GENE EXPRESSION OF FILIAL RATS.

Cytosine methylation silences transposable elements in plants, vertebrates, and fungi but also regulates gene expression.

Then the SOM network is used to cluster the yeast gene expression data.

The first step is to cluster gene expression data.

Promoter is key regulation element in gene expression. It is very important to choose the effective promoter in transgenic plants.

Recently, it was found that mrna had something to do with regulating gene expression and cell cycle.

The group also found that in young leaves ORE1 was held in check by microRNA, a kind of small molecule that controls gene expression.

Changes in gene expression may help explain why so many diets fail.

Since then, we have seen the development of molecular biology, work on gene expression and studies on the enzymatic properties of proteins.

Palmitate also increased IL-6 and SOD2 gene expression, and this effect was prevented by inhibiting NFB.

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene expression.

P&G recently compared gene expression in skin samples from the buttocks and forearms of 10 young and 10 older women.

The analysis of differential gene expression and the study on signal transduction would shed light on cropheterosis at molecular level.

AIM: To explore the effect of aldosterone on visfatin gene expression and secretion in 3T3-L1 preadipocytes or adipocytes.

Currently there are gene expression information of rat, mouse, human and some other species.

There are multi -scale feature gene expression, the maximum classification rate is 98. 61%, with stable results.

We also used several gene expression data to implement our proposed method to prove it can work effectively.

The factors, such as the second messagers in cells, glucocorticoid, PKC etc, may regulate the gene expression of potassium channels.

We found that simple changes have a powerful impact on gene expression.

In the last year, several new findings about epigenetic modifications of gene expression were reported in different arthritides.

This event triggers the "closure" of DNA structure and shuts down gene expression, such as E-cadherin.

In the third chapter, first of all, a single-gene expression model with two delays is given.

Conclusion: The gene expression map of the normal peripheral blood was established. KPNA4 and SPG3A may be related to the development of IA.

It is a method to design antisense nucleic acids based on hybridization in order to regulate gene expression artificially.

Many human diseases, such as diabetes, are caused by a disorder of gene expression.

If we can target gene expression specifically to cones [in humans] then this has a tremendous implication.

The gene expression level was higher under drought stress than that under normal conditions.

Objective To study characterizing the gene expression profile alterations associated with laryngeal squamous cell carcinoma.

Now there are several feature selection methods applied to gene expression data, such as Sequential Forward Selection, GA, S2N and so on.

Objective To study the proliferative change of epithelium and gene expression in adenoma-carcinoma sequence of gallbladder carcinogenesis.

Agilent, based in Palo Alto, California, has developed biochips that contain DNA microarrays to study gene expression patterns.

AIM: To study the effect of dexamethasone (DEX) on the adrenomedullin (ADM) and its gene expression in lung tissue of asthmatic rats.

To study the relationship of hepatocyte apoptosis and gene expression of liver cirrhosis and primary hepatic carcinoma.

Objective: To study the effects of cyclic tensile stress on the gene expression profiles of human osteoblasts in vitro.

Not only to enhance the VTG gene expression level in female carb, but also can induce VTG gene expression in the male crab.

AIM: To study the influence of Tangshenping capsules on gene expression of the big blood vessel of diabetes mice.