egfr

Therapeutics targeting epidermal growth factor receptor (EGFR) are unable to effectively inhibit tumor growth in a majority of cases.

Results: Expression of EGFR in non-atrophic gastritis was the lowest among the various gastric mucosal lesions (P01).

But the generally limited response to these treatments has caused cancer experts to wonder if EGFR's role in the disease is limited as well.

Inhibition of EGFR may be a promising adjuvant in chemotherapeutic strategy in the treatment of the dismal disease.

Interpretation: EGFR-inhibiting antibodies compromised the renal magnesium retention capacity, leading to hypomagnesaemia in most patients.

Methods: Immunohistochemistry was used to examine the immunolocalization of EGFR during mouse first lower molar development.

In the first set of experiments, the researchers demonstrated that the kinase domain of EGFR is normally maintained in the off state.

The molecular targeted drugs include epidermal growth factor receptor(EGFR) inhibitors, angiogenesis inhibitors and apoptosis promoters.

Irrespective of pathology, anti-EGFR monoclonal antibody-induced severe hypomagnesaemia does not occur in all patients.

Isoflavone . Inhibitor of EGFR tyrosine kinase, blocking phosphatidylinositol turnover.

Objective To investigate the relationship of epidermal growth factor (EGF) and its receptor(EGFR) with fetal birth weight.

Abstract: Objective To determine the role of epidermal growth factor receptor (EGFR) signaling in bone development in mice.

Objective As EGFR inhibitor, Cetuximab has been widely used in several solid tumors, and has perfect therapeutic effect and security.

To determine the role of epidermal growth factor receptor (EGFR) signaling in endochondral ossification.

A total of 2281 patients with NSCLC were screened for EGFR mutations in their tumors and, of this group, 327 had mutations.

In their structural studies, those scientists had found only the active conformation of EGFR in their protein crystals.

Estimated glomerular filtration rate (eGFR) and diastolic blood pressure showed no significant seasonal variations.

The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies.

Activating mutations in EGFR in cancer cells from patients who had a response to these drugs were subsequently discovered.

Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.

Erbitux slows the progression of colorectal cancer, but the drug's activity does not correlate with expression of EGFR in such tumours.

an increase in the number of cells was associated with tumor progression, with the emergence of additional EGFR mutations in some cases.

The results also demonstrate that EGFR signaling pathway is an important target in pancreatic cancer.

Conclusions: Basal cytokeratin and EGFR expression are both highly prevalent among triple-negative breast cancers.

EGFR inhibitor has got a promising efficacy in the treatment of non-small cell lung cancer and head and neck tumor.

Targeting EGFR pathway as a potential therapeutic strategy for pancreatic cancer has been developed.

Objective To explore the expression change of protein and mRNA of EGFR(epidermal growth factor receptor)in RAU(recurrent aphthous ulcer).

Our study suggests a pivotal role of the EGFR-signalling pathway in regulating magnesium homoeostasis.

Would you be more willing to conduct the EGFR mutation tests for your patients based on what you just read?

Objective: To explore the significance of abnormal expression of HB -EGF, EGFR in endometrium of unknown reason infertility.

The invention provides a method for preparing a freeze-drying preparation of an EGFR-antibody.

The KRAS proto-oncogene product lies downstream of EGFR, and the mutation frees the receptor from normal regulation in cell-growth control.

Breast Cancer is the commonest malignant epithelial tumor for women. Breast Cancer also has high expression of EGFR.

Do regular pathology, VEGF, EGFR and immunohistochemical method CD34 expression and mark observation capillary is calculated.

It targets a protein - epidermal growth factor receptor (EGFR) - which drives tumour growth.

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Which of the following statements best describe your attitude towards EGFR mutation testing?

Conclusion The inadequate expression and unproportional distribution of EGF and EGFR may be related to the incidence of hypospadias.

Methods The expression of EGF and EGFR was detected in the prepuce tissue from 15 boys with hypospadias using immunohistochemical technique.

Calcium image and inhibiting test were performed to show the mechanism of LPS induced EGFR phosphorylation.

Several phase I studies have also been performed to assess the feasibility and efficacy of EGFR TKIs in combination with radiotherapy.

Will you use for all EGFR mutation positive patients? Or only a certain proportion? What other subgroups would you use for?

However, inhibition of EGFR signaling with AG1478 significantly decreased osteoclast formation compared with control group with DMSO (P01).

Future studies should address the effects of exposure and target affinity.

Therefore, it would also provide necessary evidence to test EGFR mutations for the use of Gefitinib in CRCs.

A phase I clinical trial was conducted to evaluate the safety and biologic effects of EGFR AS.

Evolution of the more specialized mechanism has ultimately enabled more specific and responsive control of the family of EGFRs.

The frequency of expression of basal cytokeratins and EGFR was similar in women with and without BRCA1 mutations.

In healthy cells, EGFR triggers growth in response to an activating signal that comes from outside the cell.

In some cases, tumors that would normally have killed mice in 20 days were stable for months with the blocked expression of mutant EGFR.

Baseline levels of high EGFR and low STAT3 may be associated with antitumor effects.

What are the top 3 barriers to EGFR mutation testing? Why do you say that? What can help you overcome these barriers?

OS was significantly affected by post study EGFR inhibitor use.

But these drugs called EGFR inhibitors, such as cetuximab, have not been very effective against colon cancer.

Methods We analyzed 790 human glioblastomas for deletions, mutations, or expression of NFKBIA and EGFR.

Objective: To observe the effect of Shugan Hewei Pill on the protein expression of EGFR of the gastric mucosal of rats.

Doctor, I would like to find out more about EGFR tests from you.

Why did you choose this statement? Why do you not use any EGFR mutation testing on your patients?

Objective: To study clinical significance and expression of epidermal growth factor receptor (EGFR) in the breast carcinoma.

Objective: To study the biological roles of epidermal growth factor receptor (EGFR) during mouse molar development.

Objective: To study the role of epithelial growth factor receptor (EGFR) and NM23 in the development of gestational trophoblastic disease.

The distribution and stability of fluorescent-labeled EGFR antisense oligonucleotide in human retinal pigment epithelium

The Expression of EGFR in Gastric Carcinoma and Precancerous Lesion and its Clinical Significance

Expression and its clinical significance of EGF, EGFR in bladder transitional cell carcinoma

EGFR expression in cerebral gliomas and its correlation with proliferation and invasion

Progress of Study on the Relationship of EGFR and its Signal Transduction Ways and Recovery of Gaster Mucosa Wound

Construction of the Recombinant Adenovirus Vector with EGFR Antisense cDNA of Controlling Cell Cycle

Influence of Stagnation-Removing and Muscle-Producing Method on the Levels of EGFR and FN of Experimental Wound Granulation Tissue

Expressions and Clinical Significance of Osteopontin and EGFR in Esophageal Squamous Cell Carcinoma

Inhibitory effect of antisense oligonucleotides on EGFR mRNA and protein expression of retinal pigment epithelial cell in vivo

there was sufficient material for analysis of basal cytokeratins and EGFR;

Immunohistochemical study of EGFR in the developing brain of rat

Overview of relationship between EGFR gene mutation and efficacy and acquired drug resistance of gefitinib

The Novel Application of Polyclonal Antibodies in Recognizing Anti-EGFR Inhibitors Directly from Herb

EGFR as a target for signal transduction interference therapy in human cancers

Effect of EGFR inhibitor gefitinib on proliferation and apoptosis of hepatocellular carcinoma cells

Expressions of EGFR in human maxillary sinus squamous cell carcinoma and dysplasia of epithelial tissue

Correlation between EGFR Gene Fragments with Nuclear Matrix Proteins in Bladder Cancer

EGFR mutations and targeted therapy with tyrosine kinases inhibitors in non-small cell lung cancer

The Significance of EGFR Expression in Squamous Cell Carcinoma and Adenocarcinoma of Lung

Expression and clinical significance of EGFR in esophageal carcinoma

Expression of EGFR in keratosis of laryngeal and the correlation with malignant phenotype

Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases

The expression and clinical significance of EGFR in human bladder carcinoma

Correlations of EGFR to neoplasm immunity and non-small cell lung cancer metastases

Expression and Significance of EGFR Protein in Model of Radiation Injury in Mouse Skin

Expression and significance of EGFR in oral squamous cell carcinoma

Expression of EGFR in thymoma and its clininical significance

Expression and clinical significance of EGFR in ovarian cancer

Progress in the Study of EGFR Tyrosine Kinase and its Inhibitors

EGFR tyrosine kinase domain stably expressed in human cancer cell line

Expression of EGF and EGFR in the sinus mucosa of patients with chronic sinusitis

epidermal growth factor receptor, EGFR

Effects of Anweitang Granule on the EGF and EGFR Expression in Gastric Mucosa of Experimental Rats

Influence of Huajushengxin ointment on EGFR and FN of diabetes mellitus rats in recovery of trauma

The roles of EGFR in relativity of pulmonary fibrosis and lung cancer

The strategy of EGFR antisense gene therapy for human tumor

Immunotherapy of EGFR-positive Tumor Based on Recombinant EGFR Phage Vaccine

Progress in the study of EGFR-targeted antitumor therapy

Effect of Weichangle on EGF and EGFR in rats with gastric ulcer induced by pyloric ligation

Epiderm al grow th factor receptor, EGFR

The study on the correlation between EGF, EGFR and lung carcinoma