epigenetic

But, mutagenic action is not the only mechanism of hereditary change, the epigenetic mechanism may also play an important role in it.

In some cases, epigenetic changes in people seem to be passed on to subsequent generations.

Epigenetic mechanism might be associated with reduced expression of FHIT in a part cases of esophageal squamous cell carcinomas.

With epigenetic drugs, it is possible to reverse aberrant gene expression profiles associated with different disease states.

At this time I would also like to see some effort "in the Department must live, death epigenetic" shadow.

Recently, the concept that epigenetic, as well as genetic, events might be central to the evolution of human cancer is re-emerging.

But it's hard to tell in most natural populations whether inheritance is due to DNA sequence variation or epigenetic changes.

The nature of these reactions means epigenetic processes are susceptible to chemical intervention in a way that genetic mutations are not.

DNA methylation is one of the most common epigenetic events occurring in human genome and is implicated in cancer.

The main cause of these problems may be attributed to the epigenetic reprogramming of somatic donor genome.

Methylation is an epigenetic modification to one's DNA that changes a gene's activity, generally reducing that activity within the genome.

In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer.

Methylation of cytosine residues is one of the most versatile mechanisms of epigenetic regulation.

One critical factor of these developmental failures of cloned embryos is the aberrant epigenetic reprogramming.

It may be that epigenetic changes could be reinforced by mutations in the DNA, making them stable and heritable in the conventional way.

Scientific development is pregnant with a breakthrough, epigenetic studies are pushing the genetics forward.

There is now evidence that environmental events can directly modify the epigenetic state of the genome.

Genomic imprinting is an epigenetic phenomenon of the monoallelic expression of genes depending on their parental origin.

In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising.

One of the best known epigenetic factors is DNA methylation, which is a major mechanism for regulation of gene expression.

Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA.

DNA methylation is an important epigenetic modification which regulates a number of biological processes.

Researchers have found that liver cells undergo epigenetic modifications that vary with the time of day.

Epigenetic modifications are often retained when cells divide, and can sometimes be passed on to offspring.

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

Epigenetic marks, such as the modifications of the histones, are also important for the specialisation of the body's cells.

DNA methylation is one of the most common epigenetic events in eukaryotic cell.

In principle, drugs could tinker with the epigenetic code to turn entire sets of rogue genes on and off .

Disruptions to the normal epigenetic pattern of the cell can serve as biomarkers and are important determinants of cancer progression.

Recently, it has been shown that germ-cells, too, are subject to epigenetic change, sometimes in response to environmental stimuli.

The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.

Aberrant DNA methylation is one of the major characteristics of tumor cells in addition to genetic and other epigenetic alterations.

A similar question remains for the inheritance of the epigenetic characteristics from parents to offspring.

The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

Most epigenetic studies have been limited to a cellular context or have looked at the epigenetic effects of drugs or diet in utero.

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the expression and mobility of transposable elements (TEs).

These findings provide a mechanistic basis for developmental regulation of splicing outcome through heritable epigenetic marks.

DNA methylation, catalyzed by methyltransferases, is a normal epigenetic DNA modification approach in eukaryotic cells.

Sequencing-based approaches now allow high-resolution, genome-scale investigation of cellular epigenetic landscapes.

Predisposition is based on interactions between the genome and environmental influences acting through epigenetic modifications.

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.

Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression.

Here we review recent studies suggesting that imprinting results from global epigenetic changes that occur during female gametogenesis.

Furthermore, non-coding RNAs could induce epigenetic modification, which facilitates plants to adapt to the grafting-caused stress.

Geneticists have yet to decipher the complex code by which epigenetic marks interact with the other components of the genome.

Cancers arise through the accumulation of genetic mutations and epigenetic modifications.

Epigenetic variations "could explain the odd discordance of diseases among identical twins, " Whitelaw suggests.

BACKGROUND: Gene promoter methylation is an epigenetic event leading to gene silencing.

The epigenetic techniques will apply to clinic for diagnosis, prognosis, chemosensitivity and treatment of gastric cancer.

DNA methylation is a major epigenetic modification and plays a crucial role in embryonic development and placentas'development.

Background: Histone acetylation as an epigenetic change is widely studied in cancer.

Their article outlines inherited epigenetic variation in bacteria, protists , fungi, plants, and animals.

This epigenetic information can be introduced by cytosine methylation and by marking nucleosomal histones.

Cancer is a disease initiated by a series of cumulative genetic and epigenetic changes that occur in a normal cell.

This meeting will focus on genetic, epigenetic and biochemical mechanisms underlying the pathogenesis of diabetes.

And yet even if epigenetic inheritance doesn't last forever, it can be hugely powerful.

Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells.

This latest study focuses on what are called the "epigenetic" mechanisms which can affect whether a gene is expressed or not.

pins pushed into each tube represent the chemical tags of each chromosome's epigenetic code.

epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.

Epigenetic changes represent a biological response to an environmental stressor.

Researchers used "epigenetic" drugs routinely employed for non-malignant conditions.

This gene regulation is accomplished by epigenetic processes that control gene expression without altering DNA.

The current status of the epigenetic regulation of tumor suppressor genes is discussed in this review article.

Free radicals provide a very good case study of how epigenetic processes play out.

A series of both genetic and epigenetic factors have been implicated in the genesis and progression of prostate cancer.

This finding could be explained by sex-specific genetic, epigenetic, or non genetic mechanisms.

Epigenetic changes are heritable changes to the regulation of a cell's genes, caused by extra molecules being attached to those genes.

DNA methylation is one of the most important and distinct forms of epigenetic modification.

Here we discuss emerging evidence that highlights the possibility that replication timing is causally linked with epigenetic reprogramming.

It might therefore be that epigenetic therapies can effect changes which stop a cancer growing without having to kill all its cells.

Like genetic mutations, epigenetic changes can pass from one generation of cells to the next.

Chronic kidney disease is subject to the double impact of genetic and epigenetic modification.

In cancer, the dynamics of genetic and epigenetic gene silencing are very different.

Whereas cells doggedly protect their DNA against mutation, they routinely add or erase epigenetic marks.

What's more, they noted, abnormal epigenetic regulation has been seen in cancer, some types of autism, and schizophrenia.

DNA methylation is a prominent epigenetic mark and extensively found within plant genomes.

There were also significant similarities between iPSCs and cells of origin in factors related to the epigenetic control of gene expression.

Improving technologies are now providing a broader look at the epigenetic changes linked to environment and behavior.

This technique opens new ways for analyzing epigenetic mechanisms in S. mansoni at a whole-genome scale and on the level of individual loci.

These techniques are revealing in great details massive epigenetic changes in cancer.

Such epigenetic mechanisms permit a common genotype to producemultiple possible phenotypes.

For Paro, epigenetic mechanisms form an additional, paramount level of information to the genetic information of DNA.

Another paper, from January 2010, shows that the genes in ART embryos bear different epigenetic marks than non-ART embryos.

The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development.

Sweatt's lab and others have since found evidence that epigenetic mechanisms play important roles in learning and memory in adult rodents.

Her son is born star, her epigenetic Bodhisattva is accompanied, she eventually flying.

Biological stress in plant pro-vises an inherent epigenetic driving force of evolution.

There is some evidence that the environment causes epigenetic changes that make people more susceptible to asthma.

These what-are-called epigenetic changes signal to the muscles to, well, tone up.

Histone lysine methylation plays a key role in epigenetic regulation.

And drinking and smoking can have epigenetic effects in offspring.

Unlike the stable genetic code of DNA, many epigenetic marks are in constant flux.

The epigenome, however, is occasionally a wishy- washy supervisor. In some cases, epigenetic "decisions" can be reversed, Jirtle said.

A delicate analysis of epigenetic karst of Leikoupo Formation in Longgang area has further proved the view above.

But epigenetic changes are not typically as stable as changes in DNA sequence.

Its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells.

During sperm development, which is occurring constantly in the male, epigenetic marks are erased and replaced.

It includes epigenetic uranium impregnations in sandstone.

But because the DNA code itself remained unchanged, Morris's team suggest that the changes in gene expression are epigenetic.

When animals are cloned, epigenetic changes can occur.

Gene silencing is a kind of epigenetic phenomenon discovered in transgenic plants in recent years.

Recent reports suggest that the multi drug resistance-1 (MDR1) gene is regulated by epigenetic mechanisms.

In addition, the epigenetic state determines whether these alleles are dominant.

Unlike the human genome, however, the epigenetic code hasn't been mapped.

Instead, there are 'epigenetic' chemical tweaks to the genes, altering how they are expressed in the offspring.

Although neither GSK2816126 nor JQ1 is ready for human trials, two other sorts of epigenetic drugs are already on the market.

But how did epigenetic regulation arise?

There are four known mechanisms for epigenetic inheritance.

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types.

They now know that when the gametes are formed, certain epigenetic markers remain and are passed on to the offspring.

DNA methylation, amongst the known epigenetic modi? cations, appears to play a crucial role in leukaemogenesis.

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene expression.

In 2004 the Food and Drug Administration (FDA) approved an epigenetic drug for the first time.

In all, the cancer stem cell theory and the development of epigenetic may cast new lights on differentiation therapy of HCC.

In the last year, several new findings about epigenetic modifications of gene expression were reported in different arthritides.

But Dr Szyf still wanted to know what triggers epigenetic tagging in response to maternal care.

Geochemical Characteristics of Epigenetic Alteration in Dongsheng Sandstone-type Uranium Deposit and its Metallogenic Signification

Mechanisms of Epigenetic Reprogramming in Mammalian Reconstructed Embryos Produced by Nuclear Transfer

Molecular Genetic and Epigenetic Mechanisms of Hepatocarcinogenesis

Discussion on spatial emplacement of exogenic-epigenetic infiltration-type uranium deposit

Evidences of the epigenetic mineralization process and geochemical features of Mujiazhuang copper deposit

The epigenetic regulation of HOX family genes in early osteogenetic differentiation of human mesenchymal stem cells

Epigenetic Modifications and Its Impact on Animal Cloning

Expression and epigenetic modification of tumor-associated genes in human colonic cancer cells

Epigenetic alteration of sedimentary rocks at hydrogenic uranium deposit

The Epigenetic Pathogenesis of Systemic Lupus Erythematosus

Epigenetic Mechanisms and Therapy of Tumorigenesis;

DNA Methylation in Plants and Its Epigenetic Function

The Influence of Epigenetic Water irrigation to Antioxidant Enzymes in Winter Wheat

Progress of Epigenetic Study on Nasopharyngeal Carcinoma

Epigenetic Reprogramming of The Genome in Cloned Animals

Research of Epigenetic Pharmacology in Cancer Chemotherapy of Tumor

The importance of such "epigenetic" inheritance is controversial;

The roles of histone lysine methylation in epigenetic regulation

Epigenetic Reformation of Rock Mass in Dam Area of Xiluodu Hydropower Station

Epigenetic regulation for prevention and gene therapy of tumors

Epigenetic Modification of Ovary Cancer

Genetic and epigenetic effects of DNA methylation in cancer

Progress of Research on Epigenetic and Human Disease

Progress and research in epigenetic therapy of tumor

After nine zero, the young epigenetic;

The New Advances of Epigenetic Research

Epigenetic Changes in Cancer Caused by Non-genotoxic Agents

Epigenetic Code is Chaos in Cancer Cell

The development of the studies on genetic and epigenetic control of tumors

Pay great attention to epigenetic studies of tumors

Epigenetic Effects in the Development of Characters