endothelial

Her team is now testing to see whether stem cells will turn into endothelial cells in the channels and into muscle cells elsewhere.

He said that measuring levels of circulating apoptotic endothelial cells might be a useful marker to fine-tune CPAP therapy.

In two-dimensional cultures the primary cardiac endothelial cells arrayed into a cobblestone-like structure.

Leptospires with different virulence did not cause significant changes in permeability of endothelial monolayers.

This was followed by the formation of an endothelial opening through which emboli translocated into the perivascular parenchyma.

Stem cell mobilization did not occur in knock out mice lacking genes for endothelial . NO synthase.

Vascular Endothelial Growth Factor and its receptors may be the pivotal stimulants in the process of growth and metastasis of a neoplasm.

While red blood cells are carried away at a high velocity by a strong blood flow, leukocytes roll slowly on endothelial cells.

The thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.

Vascular endothelial growth factor is only one endothelium specific growth factor that plays a pivotal role in angiogenesis.

Conclusion Taurine with concentration between 2% and 6% has no adverse effects on the growth of rabbit corneal endothelial cells.

We present a case of intravascular papillary endothelial hyperplasia presenting as a soft tissue mass in the triceps muscle.

The vascular permeability, estimated by the quantity of supernatant passing through the endothelial tissue, appeared significantly higher.

The vessels stained positive for antibodies to human endothelial cells, again showing that some of the cells had to come from the tumor.

It was proved that endothelial cells could grow on the surface of Ti-0 film which immobilized with albumin and heparin.

At various time periods after operation, endothelial cell coverage had no difference between the two groups.

After the first physical sessions, in fact, the blood of these patients showed an increased number of endothelial progenitor cells.

Objective To investigate the expression and its significance of vascular endothelial growth factor (VEGF) in gallbladder carcinomas .

Puzzle or Hope? Are Endothelial Progenitor Cell Capture Stents the Next Potential Treatment for Restenosis?

Angiosarcomas demonstrated an extravascular proliferation of atypical epithelioid endothelial cells, and mitotic activity.

Nitric oxide(NO)is an endogenous compound, which protects both gastrointestinal mucosa from injury and vascular endothelial function.

Objective: To develop a new method for a tissue engineered vascular graft combining endothelial cells and an acelluarized allogenic matrix.

These results suggest that these transplantable corneal endothelial cell sheets can be applied to treat patients with damaged corneas.

The intracellular location regulatory of endothelial nitric oxide synthase is the important part of the regulation of post-translation.

Objective To explore the expression of vessel endothelial growth factor (VEGF) in gastric carcinoma and its clinical significance.

Vascular endothelial growth factor (VEGF)in colon adenoma between the different expression of TCM are significant differences.

Cancers secrete a variety of growth factors to attract the endothelial cells that build new blood vessels in a process called angiogenesis.

Importantly, endothelial markers were expressed by cells at all stages of heterotopic ossification.

OBJECTIVE: To explore the changes of vascular endothelial growth factor during the progress of glucocorticoid induced osteonecrosis.

The injection of endothelial progenitor cells is promising to become a novel approach for the treatment of cardio-cerebrovascular diseases.

Vascular endothelial growth factor is an important angiogenic factor, which mainly produced by vascular endothelial cells.

Vascular endothelial growth factor-A (VEGF-A) has recently been recognized as an important neuroprotectant in the central nervous system.

Morphological observation under inverted microscope, endothelial cells were spindle-shaped or polygonal, the size uniformity.

Congenital lymphatic and vascular malformations and infantile hemangiomas can be combined under the heading of endothelial malformations.

VEGF is a marker of cervical carcinoma metastasis. vascular endothelial cell growth factor, cervical carcinoma, immunohistochemistry.

It stimulates endothelial cell proliferation and vessel hyperpermeability, promotes cell migration, and inhibits apoptosis.

Tyrosine kinases from the vascular endothelial growth factor and epidermal growth factor receptor families are the most pursued targets.

RESULTS: Sarcoma cell migrated through a gap between adjacent endothelial cells into collagen gel.

Oral administration of blueberry extract represents a potential therapeutic strategy [against] endothelial cell tumours in children.

USPIO-PLL, as an intracellular contrast agent, can label endothelial progenitor cells with high efficiency.

Conclusion Photochemotherapy may inhibit the angiogenic ability of endothelial cells through down regulating the expression of integrin.

Objective To determine the clinical aloe of vascular endothelial growth factor (VEGF) in serum in patients with uveal melanoma.

The diffusive coefficient of endothelial-cell (EC) keeps constant in normal tissue out of tumor.

Objective: To detect the expression of vascular endothelial growth factor(VEGF)and its receptors (VEGFR) in nasal polyp.

Objective To investigate the expression of vascular endothelial growth factor in articular cartilage from patients with osteoarthritis.

It has been popularly accepted that vascular endothelial growth factor (VEGF) is the most potent angiogenic factor in tumor angiogenesis.

The endothelial cells might participate in the fusion of the outflow tract ridges by endothelial-mesenchymal transformation.

Injuries of Vascular Endothelial Cells Due to Hypoxia Environment Among Young Soldiers Rapidly Entering Plateau.

vascular endothelial all growth factor; Breast; Breast cancer; immunohistochemical methods.

CONCLUSION: APN inhibits apoptosis and protects endothelial cells against lipid peroxidation insult by scavenging the free radicals.

Objective To prepare and identify monoclonal antibodies against vascular endothelial cells in hepatocarcinoma.

Circulating endothelial cells, as the potential source of endothelial cells, have certain clinical application values.

Vessels of the outer membrane and middle muscle tissue, both from the original endothelial cells surround stroma development.

Massive osteolysis remains an enigmatic condition that involves various skeletal locations and is caused by endothelial proliferation.

Endothelial cells, epithelial cells in the basement membrane and together constitute the glomerular filtration membranes.

Indeed, we recently observed impaired apoptotic regulation of endothelial cells in lung biopsy samples from patients with irreversible PAH.

Endothelial cells(ECs) consist of a heterogeneous population covering the entire inner surface of blood vessels.

Conclusion: The expresion of E - Selectin seemed to be relevant with endothelial cell injury.

The immunofluorescent staining indicated that the positive rate of the endothelial cell marker CD34 was higher than the other two groups.

ConclusionMononuclear cells can be induced and differentiated into endothelial progenitor cells in vitro.

Colonic inflammation produces memory T cells that have the ability to bind both biliary and colonic endothelial cells.

Endothelial cells, which line blood vessels, can be prepared from a variety of tissues.

The same growth velocity and cell morphology were observed in the corneal endothelial cells from the right and left eyes of the same rabbit.

Objective To investigate the effects of photochemotherapy on the angiogenic ability of endothelial cells and expression of integrin.

In the microvasculature, these include endothelial cells, pericytes (in retinopathy), and podocytes (in renal disease).

The morphology of the leptospires penetrating the endothelial monolayers were observed by transmission electron microscopy.

E-selectin finds its expression in endothelial cell surface stimulated by the cytokinin, mainly in the post-capillary venules.

This intraceptor traps vascular endothelial growth factor, or VEGF, inside the protein making machinery of a cell.

Four types of cysts are observed: parasite cysts, epithelial cysts and adenomas, pseudocysts, and endothelial cysts.

Objective To investigate expression of vascular endothelial growth factor in adenomyosis and to explore pathogeneses of adenomyosis.

CE: Every western meal of processed vegetable oils, dairy products, and meat (including chicken and fish) injures these endothelial cells.

Objective To evaluate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis , and its usage in tumor therapy.

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in keloids and hypertrophic scars.

The diagnosis was intravascular papillary endothelial hyperplasia.

METHODS: Rabbit endothelial cells were cultured by standard enzyme separation technique and cell culture technique.

Endothelial nitric oxide synthase transcription decreased with treatment.

And above all they contain saturated fat which immediately injures the endothelial lining of the arteries when eaten.

The organelle of endothelial cells changed obviously. The distribution and morphology were changed evidently in the normal region.

Objective: To investigate the expression and role of vascular endothelial growth factor (VEGF) in cervical carcinoma tissue.

Finally, the team added a layer of the patient's own endothelial cells, which promote smooth blood flow, on the inside of the vessel.

Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?

This article analyses factors relate corneal endothelial damage including inside factors and outside factors.

Conclusion CPB can induce activation damage of vascular endothelial cell, and increase vascular permeability.

Conclusion: Trypsinase digestion is an effective way to cultivate the human umbilical vein endothelial cells in vitro.

fresh umbilical core was provided by Department of Obstetrics, Weifang People's Hospital for endothelial cell isolation and culture.

abstract: Objective: To explore the culture and identification of the human umbilical vein endothelial cell(HUVEC)in vitro.

The recombinant fusion protein can inhibit the proliferation of endothelial cells and perform a function for preventing tumors.

Aim To investigate the effects of gene expression through activating endothelial target for acetylcholine ( ETA).

Aim To explore the role of endothelial gap junctions in intercellular communication and vascular endothelial wound repair.

Methods Bovine endothelial cells were isolated from calf thoracic aorta by enzyme digestion methods and sub cultured and purified.

Conclusion The results suggest that it is a useful method for study on cultured endothelial cells and tissue engineering.

The obturated haemocoel was enclosed by the continuous and stratified basement membrane under the coelothelium and endothelial.

In contrast, knockout mice deficient in the endothelial form of NOS have larger infarcts than normal (62).

Endothelial cells manufacture a magical protective molecule of gas called nitric oxide, which protects our blood vessels.

Objective: To investigate the effects of trimetazidine on endothelial cells in patients with coronary heart disease.

This review reveals the latest advances in the mechanism of apoptosis in corneal epithelium, stroma, endothelial cells in the course of HSK.

Activated neutrophils adhere to vessel endothelial cells and release oxygen free radical and enzymes of cell disruption.

Vascular endothelial growth factor(VEGF)is a specific vascular growth factor, which paly an important role in the angiogenesis .

The basic pathology is apoptosis of the vascular endothelial cell and oligodendrocyte.

Auto-immune reaction mediated by specific factors is the major mechanism underlying endothelial damage.

We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes.

Results The NOS primarily distributed in the syncytiotrophoblast and vessel endothelial cells.

Local coronary production of lysophosphatidylcholine, the active product of Lp -PLA2, is associated with endothelial dysfunction.

Objectives To evaluate the expression and the role of vascular endothelial growth factor in the lesion of Cutaneous malignant melanoma.

In addition, endothelial cell counting as well as intra-corneal pachymetry can be performed.

Objective: To review the advance on regulation of vascular endothelial growth factor(VEGF) in tumor tissue by natural drugs.

Poly D, L-lactic acid based shape memory polymer (PDLLA-PUU SMPs) with human umbilical vein endothelial cells were cultured in vitro.

This is an image of an endothelial cell attached to synthetic microfibers, stained with microtubules, F-actin and nuclei.

Oligodendrocyte and Capillary endothelial cells in Cerebrum and Cerebellum.

Vascular endothelial growth factor (VEGF)expression in adenomas was significantly higher than in normal colon tissue.

By immunohistochemistry, MMP - 2 was expressed in sinusoidal endothelial cells, vascular endothelial cells and sinusoidal cells.

Objective To investigate induction of endothelial progenitor cell(EPC)from peripheral blood.

The influence of human umbilical vein endothelial cells on vascularization for acellular porcine dermis.

When fluid begins flowing through these channels, endothelial cells move in to line the channels while muscle cells move away.

OxLDL causes endothelial activation and changes its biological characteristics in part by reducing the intracellular concentration of NO.

Hypertension can damage endothelial cells and shrink it, leading to easy access to the vessel wall lipoprotein.

Previous studies shown that LDM have could inhibit the proliferation and migration of endothelial and tumor cells.

Endothelial growth factor (VEGF) in retinal and choroidal neovascularization play a key role in the occurrence.

A high proportion of progeny cells express receptors for vascular endothelial growth factor-2 and for stromal derived growth factor.

Like EPO, vascular endothelial growth factor spurs red-blood-cell formation and thus helps to supply tissues with oxygen.

Methods Monoclonal antibodies were prepared with the mice that immunized by human umbilical vascular endothelial cells (HUVEC).

Objective: To understandthefunctionof splenic marginal sinus endothelial cells in blood spleen barrier.

The damage of the inferior corneal endothelial cells aggravated with time passing.

We examined 2 representative growth factors: brain-derived neurotrophic factor and vascular endothelial growth factor (VEGF).

Gene expression of vascular endothelial growth factor increased in the cell-administrated group.

It can promote the adhesion and growth of endothelial cells to immobilize Laminin onto the surface of Ti-O film by amino group.

Besides, SDF-1 can promote angiopoiesis of vascular endothelial cells to provide nutritional support for the tissue repair.

Endothelial cells of blood vessel play an important role in anti-atherosclerosis, antithrombosis, thrombolysis and vessel dilation.

The capillary density(CD) and its endothelial cell area(AEC) in myocardium.

Vascular endothelial growth factor (VEGF) and cyclooxygenase (COX-2) and cerebral vascular disease, has attracted people's attention.

Results VEGF and PLGF were mainly expressed in trophoblast, next in decidua and endothelial cells, and also in stroma.

Type 2 diabetes mellitus; Diabetic nephropathy; Irbesartan; Vascular endothelial growth factor.

HCC is generally hypervascular, and vascular endothelial growth factor (VEGF) promotes HCC development and metastasis.

First, they looked for microRNAs that were enriched in endothelial cells from mouse embryonic stem (ES) cells.

AIM: To establish a convenient, cheap and stable culture system for mouse lymphatic endothelial cells.

OBJECTIVE To examine the effect of traditional Chinese medicine Banlangen injection on human vascular endothelial cells.

Methods Endothelial cells obtained from bovine retinas were cultured invitro.

Recent studies demonstrate that shear stress in vitro can enhance the nonthrombogenic factors secreted by mature endothelial cells.

The NO production was correlated negatively with LDH release and cell death rate in anoxic endothelial cells.

For instance, if stem cells are exposed to flowing fluid, they turn into the endothelial cells that line the inner surface of blood vessels.

Researchers examined cells, called endothelial cells, that line the lumen or inside of blood vessels.

Results The corneal endothelial cells were transformed quickly from tissue pieces.

Arterial wall is constituted by endothelial cells, smooth muscle cells and fibroblasts.

Can be induced to differentiate into endothelial cells in vitro.

Objective To find the morphological proof of direct communication between human umbilical vascular endothelial cells (HUVECs).

Vascular endothelial growth factor(VEGF), the key inducer of angiogenesis, overexpresses in many types of tumor.

Watching each group of abdomens aorta changing from roughly shape, histology and the endothelial cell after the medicine.

Results Binuclear and polynuclear endothelial cells were found in every buttons.

In Whites but not Blacks insulin resistance is associated with increased circulating endothelial biomarkers.

There is significant correlation between arterial partial pressure of oxygen and serum vascular endothelial growth factor.

Thin-layer culture of cardiac vascular endothelial cells showed tube-like structure and lumen.

Objective: Toinvestigatetheeffects of Danshen dripping pills on neointimal hyperplasiainrabbit iliac artery after endothelial denudation.

Objective: To establish a convenient and efficient method of primary culture of rabbit brain microvessel endothelial cells(BMVEC) in vitro.

The procedure is clearly described and provides a large population of highly purified endothelial cells.

Conclusion Monoclonal antibody against vascular endothelial cells can be made in hepatocarcinoma site and has cytotoxic effect in vitro.

Tight junctions are one mode of cell-cell adhesion in epithelial and endothelial cellular sheets.

Objective To observe tumor suppressor gene P53 and vascular endothelial growth factor (VEGF) in papillary thyroid cancer.

The circular imprints of the endothelial nuclei were also found on the cast surface of the alveolar capillaries.

ARDS is characterized by endothelial and epithelial cellular injury.

s disease. The HHV-8 sequences can be found in spindle cells or endothelial cells in Kaposi lesions.

Results Human vascular endothelial cells can well adhere to nanometeric HA film complex materials and could well multiply and grow.

It is not sure if CD31 plays an role in the interaction between the endothelial cells and cancer cells.

They had layers of distinct cells, including the endothelial calls that line natural blood vessels.

The results indicated that 911-FITC could specifically bind to lymphocytes, macrophages and endothelial cells.

Although the pathogenesis is unknown, available evidence strongly suggests that endothelial cell damage is necessary.

KDR, a receptor of VEGF, is expressed on endothelial cell of new vasculature .

The abnormal secretion of vascular endothelial growth factor greatly affects the perineonates.

All these actions of VEGF are mediated by receptor tyrosine kinase, vascular endothelial growth factor receptor (VEGFR).

A key step in angiogenesis is the up regulation of growth factor receptors on endothelial cells.

The study of vascular endothelial growth factor and proliferating cell nuclear antigen and peritumoral brain edema in meningiomas.

Much as hounds track the scent of their prey, the monocytes squeeze between endothelial cells and follow the chemical trail to the intima.

Intracellular survival and replication of Neisseria meningitidis in human brain microvascular endothelial cells.

The neointima of vascular graft formed completely, but the coverage of vascular endothelial cells was incomplete in both groups.

This article is a review of endothelial microparticles and research advances of sepsis.

Objective: To detect the expression of P-170 in astrocytes and capillary endothelial in brains of SD rats kindled by Coriaria Lactone.

Corneal endothelial cells formed round or polygon, the same size cells and lined up tightly.

VEGF is a potent agent, and trace amounts could protect the endothelial cells from death.

Endothelial cells proximal to the injury undergo rapid mitosis.

Conclusions: Local deep vein thrombosis can lead to endothelial cell injury and early apoptosis of distant vein segment.

AIM: To evaluate the effect of endothelial myosin light chain kinase on extravasation migration of sarcoma cell.

It can be concluded that CTGF was mainly produced in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts.

Tunica intima (the thinnest layer): a single layer of simple squamous endothelial cells.

When they performed the same experiment without the added omega 3s, the white blood cells easily penetrated the endothelial barrier.

Several peptides or antibodies that home to tissue-specific endothelial cell receptors were obtained by using the phage display.

If the endothelial cells become damaged, however, plaque can build up.

An experimental study on the inhibiting effect of Shenmai Injection on endothelial cell proliferation.

METHODS: Human umbilical vein endothelial cells were cultured, and randomly divided into 3 groups.

Endothelial microparticles are closely related to the advances of research of sepsis.

The medium - underlined Madeddu - contains one or more unidentified factors that stimulate endothelial cell proliferation.

Aim To investigate the effect of rosiglitazone on glucose-induced adhesion of human endothelial cells.

Microvessel density (MVD) were analyzed in CD34-stained vascular endothelial cell.

P-selections on endothelial cells interact with PSGL-1, a glycoprotein on leukocyte microvilli.

There are no changes in permeability and apoptosis of endothelial monolayers infected by leptospires with different virulence.

It can mediate leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets to leukocytes.

Many factors, such as vascular endothelial growth factor and fibroblast growth factor, can stimulate the formation of new vessels.

In addition to endothelial cells, also myometrial cells contain the enzyme implicated in the NO production.

Pentraxin 3 (PTX3) is a novel inflammatory marker produced by endothelial cells, smooth muscle cells, and macrophages.

The present study was designed to investigate whether endothelial Bmpr2 deletion can predispose to PAH.

Damaging effect on rat liver endothelial cells of tripterine in vitro.

The damages of vascular endothelial cells are the basis of many kinds of vascular diseases.

To explore the cytocompatibility of PEG-PLA-PGL tri-block copolymers with human umbilical vein endothelial cells (HUVECs).

In lung, the cytoplasm of alveoliar macrophages in alveoliar septa and endothelial cells in the capillary contained PRRS virus.

He found that substance in 1989 and called it vascular endothelial growth factor, or VEGF (pronounced VEJ-eff).

AIM: Nowadays the study on human bone marrow mesenchymal stem cells (MSCs) differentiating into endothelial cells is less.

Osteoblasts express protease-activated receptor-1 and vascular endothelial cell growth factor [1].

It has a new endothelial recovery fast, low-induced thrombosis and the degradation of suitable time (2-3 months), and other advantages.

The protective effect of WEP on endothelial cells may be synergic with inhibitor of HMGCoA reductase such as fluvastatin sodium.

Conclusion TIA and ACI are associated with endothelial injury and ET-1 elevation.

CD34 staining in vascular endothelial cell membrane.

VEGF165 is the most effective growth factor for endothelial cells among them.

RESULTS: " Ghosts" of endothelial cells and pericytes were seen in diabetes mellitus in 3 month and 6 month groups.

HIF1 can then promote endothelial and tumour cell survival.

the patency rate in control group was 60. 0%, the endothelial cell coverage was incomplete.

The number of CD14 CD16 cells correlated with both endothelial microparticles and EPCs.

The vascular endothelial cells are not only a mechanical barrier of the blood vessel but also an endocrine organ.

The study of vascular endothelial cells made that we have a deeper reognization to the vascular diseases.

More and more studies proved that the endothelial progenitor cells provide a therapeutic stratagy for the ischemic diseases and the tumor.

Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)-VEGF receptor system.

Then they added omega 3s to the endothelial cells.

It acts selectively on endothelial cells to promote angiogenesis and takes part in pathophysiology process of cerebral ischemia injury.

The several kinds of P2X and P2Y receptor subtypes have been expressed in vascular endothelial cells and vascular smooth muscle cells.

ConclusionTwo kinds of lipid-lowering drugs are inhibiting the role of endothelial cell proliferation.

Fig. 1, 2 the 2nd and 5th endothelial cells show flat short-shuttled shape or polygon and uniformity of size, and nucleus is clear.

There are also methods for obtaining endothelial cells from other tissues such as fat, skin, and mucosa.

Objective To study the changes of serum vascular endothelial growth factor (VEGF) in patients with breast cancer and its significance.

This is also being applied to endothelial cells, liver cells, fat cells and so on.

Objective To study the protective effects of light and moderate concentrations of alcohol on endothelial cells.

Objective: To study the feasibility of medulla MSCs differentiation directionally to endothelial cells.

Objective To study the relationship between vascular endothelial growth factor (VEGF) and grading (G) and staging (S) of hepatitis B (HB).

Objective To study the role of vascular endothelial growth factor (VEGF) in development and evaluating prognosis of breast cancer.

Objective: To study the autocrine function of vascular endothelial growth factor in rat osteoblast.

Objective To study the influence on vascular endothelial cell (VEC) apoptosis for Different Modelling Method.

Objective: To study the anti coagulation function of endothelial cells(ECs) co cultured with vascular smooth muscle cells(VSMCs).

Objective To study the effect of vascular endothelial growth factor(VEGF) on portal hypertensive gastropathy(PHG).

Objective To study the effects of Tongluofangji on the antioxidative system and aorta thoracic endothelial in diabetic rats.

Objective To study the intervention of Daotan Decoction to the expression of ICAM-1 in cerebrovascular endothelial cells.

Effects of high cholesterol diet and parallel atorvastatin treatment on the surface structures of aortic valve endothelial cells

AIM: To study the protective effect of medicinal serum of Jiangtang compound recipe on endothelial cells which were damaged by H2O2.

Objective To study the effect of Simiaoyongantang on human umbilical vein endothelial cells (HUVECs) injury induced by hypoxia.

Preliminary study of the isolation, cultivation and biological characteristics about liver sinusoidal endothelial cells in rats

Study of the relationships between endothelial nitric-oxide synthase polymorphism and pregnancy induced hypertension

Relationship between Recurrence in Colorectal Carcinomas and Expression of Vascular Endothelial Growth Factor with Its Receptor KDR

The Experimental Study of the Effects of Adenovirus-mediated Vascular Endothelial Growth Factor Gene Transfer on Restenosis

Relationship between the Vascular Endothelial Growth Factor and Receptors of Ovarian Neoplasm and Its Clinic Pathology

A Comparative Study of Different Distention Solutions and Their Preservation of Greater Saphenous Vein Endothelial Cells during CABG Surgery

Spatial expression pattern of vascular endothelial growth factor and its receptor mRNA in the early stage of acute focal cerebral ischemia

A study of adhesion of peripheral lymphocytes and eosinophils to lung capillary endothelial cells in a guinea pig asthma model

Methodological Approaches for the Morphological Study of Endothelial Cells Apoptosis on Arterial Surface

Study of the relationship between asymptomatic coronary endothelial lesions and coronary risk factors

Study on lipopolysaccharide-stimulated endothelin and adrenomedullin secretion from human vascular endothelial cells and its mechanism