COX-2

FitzGerald had begun reporting his findings at conferences in 1997, a year before approval of the first COX-2 inhibitor, Celebrex.

Another limitation, they noted, was the lack of a standardized classification system for COX-2 expression in colorectal cancer.

CONCLUSION One of antipyretic Effect mechanism of YHCE may be related to its inhibition of the protein expression of COX-2.

Interestingly, immortalization of postselection cells using various methods leads to a dramatic decrease in COX-2 expression.

Cyclooxygenase 2 (COX-2) is one of the key enzymes in the synthesis of prostaglandins. It is an inducible enzyme.

Celecoxib, which shows few side effects, is one of the high selectively COX-2 inhibitors.

COX-2 is the rate-limiting enzyme in prostaglandin biosynthesis, and is over-expressed in breast cancer.

The selective inhibitor of COX-2 has a wide future in the prophylactic-therapeutics of tumor, but many problems need to be solved in future.

Objective To investigate the expression of COX-2 in endometrial carcinoma and its relationship with angiogenesis.

COX-2 inhibitors also have been shown to cause adverse cardiovascular effects when administered at high doses over long durations .

Unfortunately, cardiovascular side-effects have recently been reported in patients using another selective COX-2 inhibitor, rofecoxib.

This article reviews recent research progress of COX-2 and its inhibitors in tumor preventing and controlling.

Vascular endothelial growth factor (VEGF) and cyclooxygenase (COX-2) and cerebral vascular disease, has attracted people's attention.

Objective To investigate the correlation between the expression of cyclooxygenase-2(COX-2) in osteosarcoma and lung metastases.

Recent researches have shown that cyclooxygenase-2(COX-2) plays a key role in pathogenesis of diabetes mellitus and its complications.

Article 2 - in patients with esophageal COX and the expression of esophageal cancer tissue generated in the relationship between lymphatics.

Objective To investigate the significance of expression of COX-2 and P-glucoprotein in hepatocellular carcinoma.

The selective inhibitor of COS-2 is a more ideal method in prophylactic-therapeutics of tumor.

Mrs. Cox teachers five of these six periods. During her "free" period from 2 to 3 p. m. , Mrs. Cox has to meet with parents.

COX-2 and VEGF-C expressions in esophageal squamous cell carcinoma tissues were detected by SP immunohistochemistry.

Recent studies implicated expression of cyclooxygenase 2 (COX-2) as a marker to identify precursor cells for breast cancer.

A join-detection of COX-2 and VEGF-Cs expression in breast cancer can provide a reference for instituting clinical treatment plan.

The expressions of proliferating cell nuclear antigen (PCNA) and cyclooxygenase-2 (COX-2) were assessed by immunocytochemistry method.

Objective To investigate the significance of expression of COX-2, VEGF and P-glucoprotein in carcinoma of stomach.

Cyclooxygenase-2(COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies.

Objective: To introduce the progress and mechanism in HCC prevention and treatment with COX-2 inhibitors.

That doesn't mean that popping a COX-2 pill will become the next weight-loss treatment du jour.

Studies find that cyclooxygenase-2 (COX-2) is associated with the genesis, development and prognosis of endometrial carcinoma.

Results Compared to that in oral normal oral mucosa and oral inflammation, the expression of COX-2was significantly higher in OSCC(P0. 001).

In this paper, we briefly review the function of COX in reproduction, the relationship between COX-1 and COX-2, and their signal pathways.

COX-2 and its inhibitors have a broad prospect in the tumor prevention, chemotherapy, radiotherapy and biotherapy.

The expression of COX-2 in gastric carcinoma was correlated with histological grade, invasive depth and lymph node metastasis(P05) .

Two-step immunohistochemical detect tumor-associated protein COX-2, CD31 antibody in tumor microvessel density.

COX-2 is progressively overexpressed during the stepwise sequence from adenoma to carcinoma, Dr.

Inflammatory cells, proinflammatory cytokines and COX-2 play an important role in the process of lymphangiogenesis.

It is significant to research the relationship between COX-2 and VEGF-C in lymph node metastasis mechanism of breast cancer.

COX-2 inhibitors reduce GI bleeding but they may increase the risk of cardiovascular events.

Objective To investigate the expression and significance of cyclooxygenase-2(COX-2) in the tissues of gastric mucosal lesion.

Study found, COX-2 was overexpressed in the majority of malignant carcinomas including tongue squamous carcinoma.

Thus the research of COX-2 inhibitors for treating breast cancer becomes a hot issue at present.

A high intensity of COX-2 also predicted biochemical failure, the immediate PSA rise after treatment.

Cyclooxygenase-2(COX-2) expression in each group of endometrium and endometriotic tissue was observed by immunohistochemistry method.

The expression of COX-2 and VEGF has notable direct correlation with P-glucoprotein.

COX-2 plays an important role in the growth of tumour cells, apoptosis, and the angiogenesis of tumour.

Objective: To synthesize valdecoxib, a COX-2 inhibitor.

Novel compositions comprising Hippophae rhamnoides extracts that preferentially inhibit COX-2 over COX-1 are provided.

The role of selective COX-2 inhibitors in patients with FAP is controversial because of cardiovascular side-effects reported for rofecoxib.

Selective cyclooxygenase-2 (COX-2) inhibitors have received increasing attention for their role in the prevention and treatment of cancer.

COX-2 is induced in physiological conditions, COX-2 in most tissues at very low copy number expression.

The expression of COX-2 in 33 cases with chronic hepatitis and 17 cases with liver cirrhosis was detected by immunohistochemistry.

In this study, we analyzed COX-2 expression in preselection and postselection hMEC cells and observed similar COX-2 levels in both cells.

COX-2 affects inflammation, which may play a role in tumour growth.

It had no effect on tumors with weak or absent expression of Cox-2 (multivariate relative risk, 0. 96, CI 0. 73 to 1. 26).

COX-2 promotes inflammation, but COX-1 protects the lining of the stomach.

COX-2, which is the inducible form, involved in inflammation and cancer incidence.

Nor does it mean that COX-2 inhibitors, which repress COX-2 activity, will necessarily lead to weight gain.

If an NSAID inhibits both COX-1 and COX-2, GI bleeding and ulcers can result.

Cyclooxygenase-2 (COX-2) is the key enzyme which catalyzed arachidonic acid into prostaglandin E2 (PGE2).

In contrast, with absent or weak COX-2 tumors, regular or nonregular use of aspirin made no difference.

Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas.

Conclusion Local COX-2 may play important roles in the development of knee osteoarthritis.

COX-2 is an inducible enzyme that is associated with adverse stimuli such as inflammation, infection, and tissue injury.

The level of adiponectin and COX-2 in observation group showed obviously inverse correlation (r=-0. 215, P01).

A growing amount of evidence suggests an association of COX-2 with tumour development.

Objective To study the correlation between the expression of COX-2 and the apoptosis of PMN following chest-impact injuries in rabbits.

VEGF-C expression had positive correlation with COX-2 expression in UUTUC tissues (r=0. 675, P0. 01).

Objective To study the expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma and its relation to clinical behavior.

Prophylactic Effect of a Selective COX-2 Inhibitor Celecoxib on Carcinogen-induced Gastric Premalignant Lesions in Rats

The expression of COX-2 in primary hepatocellular carcinoma and its relation to clinicopathologic characteristic

Expressions of COX-2 in mesangial cells stimulated by high glucose and renal cortex in rats with diabetic nephropathy and its significance

Correlation of expression of COX-2 to clinical pathological characters and its catalytic products in gastric carcinoma

Expression of COX-2 in Bladder Transitional Cell Carcinoma and its Association with Tumor Cell Proliferation and Apoptosis

The expression of COX-2 in human gastric cancer and its relationship with neovascularization and tumor cell proliferation

Expression of COX-2 in the Carcinogenesis of Gastric Epithelia and Its Correlation with Cell Apoptosis and Proliferation

The expression of COX-2 in esophageal carcinoma and its relation to clinicopathologic characteristics

COX-2 expression in the early colorectal cancer and its clinical significance

COX-2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis

Expressions of COX-2 in laryngeal carcinoma and hypopharynx carcinoma and its clinical significance

The expression of COX-2 and its relationship to the apoptosis and proliferation in colorectal carcinoma

Apoptosis of gastric cancer SGC-7901 cells induced by selective COX-2 inhibitor celecoxib and its relationship with mitochondrial pathway

Expression of COX-2 and its significance in transitional cell carcinoma of the bladder

The expression of COX- 2 and its relationship to the apoptosis and proliferation in gastric cancer

Relationship between apoptosis of polymorphonuclear and expression of COX-2 following chest-impact injuries in rabbits

Effects of the alkaloid sinomenine on COX-2 activity and acute rejection in heart allografts: an experiment with rats

Expression of COX-2 and its relationship with lymphangiogenesis in gastric cancer

Expression and clinical significance of COX-2 mRNA in ovarian carcinoma, cervix carcinoma and endometrial carcinoma

Expression of COX-2 and Its Significance in Rat Uvea After Ocular Ischemia Reperfusion Injury

COX-2 expression in the H. Pylori infected gastric mucosal epithelia and its significance

Study of COX-2 expression and angiogenesis in oral malignant melanoma

Study on the relationship between polymorphism of the COX-2 gene and endometriosis and adenomyosis

COX-2 inhibitor (Aspirin) inhibited proliferation and induced apoptosis of human esophageal carcinoma in vitro

Synthesis of amide derivatives of andrographolide and their inhibitory activities on COX-2 expression

Proteomic analysis of human gastric carcinoma cells with different levels of COX-2 by two-dimensional electrophoresis

Expression of COX-2 in Cervical Carcinomas and its Clinical Significance

Study on relation between the expression of Cox-2 in liver cancer and micro - metastasis

Expression and clinical significance of COX-2mRNA in endometrium cancer and precancerous lesion

Expression of COX-2 and VEGF and their relation with cervical lymph metastases of papillary thyroid carcinoma

Study of COX-2 expression and angiogenesis in non-small cell lung cancer

The role of COX-2 inhibitors in pancreatic cancer treatment and its mechanisms

Docetaxel inducing growth inhibition in human non-small cell lung cancer cell lines and the influence in the expression of COX-2 protein

Expression of COX-2 and its prognostic significance in non-small cell lung cancer

Expression of COX-2 in gastric cancer and gastritis and its relationship with HP

Quality-quantity Cox Regression Analysis on Coronary Heart Disease with Type 2 Diabetes Mellitus

Expression and significance COX-2 in focal ischemic reperfusion injury of middle cerebral artery in rats

Expression of COX-2 and its clinical significance in non-small cell lung cancer

Toxicity of selective COX-2 inhibitor celecoxib on non-small cell lung cancer cell lines and the molecular mechanism in vitro

Effects of pravastatin on proliferation and expression of COX-2 protein in colorectal cancer cell lines

MRNA expression of COX-2 in nasal polyps assayed by reverse transcription polymerase chain reaction

Effects of COX-2 inhibitor with cisplatin on proliferation and apoptosis of pancreatic cancer cells

Expression of COX-2 protein in primary epithelia ovarian cancer of chemotherapy resistance

Relationship between expression of COX-2 and clinicopathological features in esophageal carcinoma

Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma

The modulatory effect of inosine on expression of COX-2 following the cerebral ischemia reperfusion in rats

Effect of Total Flavonoids in Scutellaria Baicalensis Georgi on Mice Peritoneal Macrophage Respiratory Burst and COX-2 Synthesis

The relationship between expression of COX-2 and angiogenesis in gastric carcinoma

Study on the Effects of Telomerase Activity by Selective COX-2 Inhibitor Celecoxib in Gastric Cancer in Vitro and in Vivo

Changes of small molecular energy and conformation in design of Cox-2-selective inhibitor

The Effect of Selective COX-2 Inhibitor on Proliferation and Infiltration Ability of Human Tongue Cancer Cell Line: an in vitro study

Effects of Electroacupuncture on Expression of COX-2 in the Spinal Dorsal Horn of Arthritic Rats

COX - 2 Protein Expression of Gastric Mucosa in Patients with Chronic Gastritis

Expression and significance of COX-2 in endometrium and muscle layer of adenomyosis

Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia

Toxic effect of COX-2 on dopaminergic neurons of substantia nigra in mice with Parkinson's disease

Expression of COX-2 protein in gastric cardia adenocarcinoma tissue

Clinical study on Cox-2 gene expression in nasopharyngeal carcinoma

Expression of COX -2 in human brain glioma and the relation to invasion of the tumor

Expression and biological activity of COX-2 gene in human gastric cancer cell lines

The Effect of Valdecoxib on Apoptosis and Expression of the COX-2 of Human Esophageal Cancer Cells

Effect of mifepristone on the expression of COX- 2 in rat eutopic and ectopic endometrium

The Role of COX - 2 Gene in the Carcinogenesis of Esophageal Squamous Epithelia

Study on effect of cox-2 inhibitor on proliferation and invasion of human gastric cancer cells

Expression of VEGF and COX-2 mRNA in laryngeal squamous cell carcinoma tissue

Influence of rofecoxib, a high selective cox-2 inhibitor, on articular cartilage of rats

The expression of COX-2 VEGF-C and lymph node metastasis in human gastric carcinoma

The role of COX-2 in focal cerebral ischemia injury in rats with diabetes mellitus

The inhibitory effect of berberine on COX-2 expression in human colon cancer cells

Expression and significience of COX-2 in metastasis foci of papillary thyroid carcinoma

Life without COX-2 inhibitors Doctors need to broaden their approach to pain in older patients

Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer

Relationship between expression of COX -2 and MMP -7 and metastasis in colorectal cancer

The Expression of COX-2 in Lung Tissue of Rats with Acute Pancreatitis

Progress in research of COX-2, a target for new NSAIDs development

Expression of COX-2 in gastric mucosa of atrophic gastritis caused by hot high-salt water in rats

COX-2 inhibitors: a novel way to prevent and treat the carcinogenesis of oral mucosa