clinical trial

To date, MTI has not been used as an outcome measure in early phase and pivotal clinical trials.

"Toxicological tests and clinical trials have not been performed on this product, " he said.

We cannot be sure that this will work as well in humans, but this is the point of performing clinical trials.

He said that this group of researchers will be undertaking larger clinical trials of oral viscous budesonide.

But now we're ready to do the big clinical trials, and our funders just don't have the money.

Tamoxifen is still a useful drug, although newer drugs called aromatase inhibitors seem to work better in clinical trials.

Ongoing clinical trials are addressing the question of the long term clinical benefit of more potent treatment regimens .

But others say that the large sum might encourage the company to put other drugs into late-stage clinical trials.

Some of these units are available in Europe, and we expect to have clinical trials with similar devices here within two years.

Some prescription drugs that were judged to perform "better than placebo" in clinical trials don't work unless you know you're taking them.

Its main scientific use at the moment is in clinical trials as a baseline for comparison with another treatment.

The chemical is also in separate clinical trials to see if it improves working memory in the elderly.

Clinical trials generally do tell a good deal about how well a medicine works for a defined disease and what potential harm it may cause.

The researchers have begun clinical trials to test the gene therapy as a treatment for a rare form of childhood blindness.

Vietnam, meanwhile, is the only developing country attempting cell-based production, and plans to run its first clinical trials this year.

Pivotal clinical trials must be properly powered based upon the level of activity shown in earlier trials and preclinical studies.

Through clinical trials and the work of feminists, viewing PMS in a social context had begun to take place.

Just to let you know that nowadays SGH has a policy of ensuring patients in clinical trials can pay for hospital costs if needed.

Jeremy Hughes, chief executive of Alzheimer's Society, said not enough clinical trials for dementia were taking place in the UK.

This review describes some of the important developments and targeted agents for pancreatic cancer that have been tested in clinical trials.

The long-term safety and efficacy of CNI withdrawal and avoidance strategies need to be further validated in controlled clinical trials.

Other challenges include the need for more clinical trials and research to be carried out on paediatric medicines.

The clinical trials indicate that its effectiveness is superior to western medicine and has no side effect.

In such situations, conventional double-blind, placebo-controlled clinical trials might not always be necessary or appropriate.

It has been shown in numerous studies and clinical trials to reduce mortality from such causes as cardiovascular disease and cancer.

Parkinson's clinical trials historically have had low participation levels, which delays the approval of new therapies.

Other important information will also be provided by results of ongoing and soon-to be-initiated vaccine clinical trials.

The Indian clinical trials don't meet current Food and Drug Administration standards and need to be redone for the U. S. market.

Human clinical trials are planned for this year to test it against the bird flu, but any mass-produced product is still several years away.

Desmond Tutu Center for AIDS Research is to undertake clinical trials of the AIDS vaccine, one of the main body.

Outstanding data from final clinical trials will probably be submitted to American drug regulators early next year, the company said.

Plans have been made to send prepared virus to pharmaceutical companies for vaccine manufacture and testing in accelerated clinical trials.

Four others, now being developed in Canada and the United States, will enter clinical trials by the end of this year.

As for therapeutic efficacy, little is known because psychoanalysts do not perform double-blind clinical trials or follow-up studies.

Clinical trials are ongoing for at least a dozen different vaginal microbicides, according to the Alliance for Microbicide Development.

The investigators are now gearing up to take the whole-cell bio sensing system through clinical trials.

It will be helpful for the administrators to supervise the clinical trials on drugs well from the point of ethical views.

Accordingly, at the request of the Food and Drug Administration (FDA), a number of clinical trials with tanezumab have been suspended.

Pelvic lymphadenectomy cannot be recommended as routine procedure for therapeutic purposes outside of clinical trials.

He said those materials, which work outside cells, are now in clinical trials.

The unpublished results look promising, Kirchhoff says, and the molecule could be ready for clinical trials by the end of this year.

Many neuroprotective drugs were proved to be effective for cerebral ischemia in animal models, but they were not proved on clinical trials.

Clinical trials often provide safety information for the general population.

This accomplishment is expected to make it possible to produce enough of the promising drugs for use in clinical trials.

The company is in discussions with the FDA regarding clinical trials.

As a consequence, a long list of would-be cures have failed in late-stage clinical trials, at enormous cost to the companies producing them.

He's conducting clinical trials of an antidepressant that changes the way the body handles a chemical called serotonin.

Several integrin-targeted therapeutic agents are currently used in clinical trials for the therapy of angiogenesis related diseases.

Aim: To understand the effect and related problems of clinical trials about acupuncture therapy for knee osteoarthritis.

Over the next three years a large number of novel, mechanistically targeted drugs will enter clinical trials for cancer.

It goes fine for a while, but Phase III of clinical trials uncovers some unexpected toxicity.

This article describes potential clinical indications and highlights the current status of the very limited number of clinical trials.

The team is about to start pre-clinical trials and hopes to have bionic tendons on the market within five years.

However, the number of new drugs access to clinical trials and markets is not increased, even on a downward trend.

Clinical trials involving a small group of human volunteers have been approved after a new drug was proven to be effective on monkeys.

Indeed, clinical trials of new combinations could be launched by the end of this year.

Other drugs to help the transplanted stem cells fight the CML without attacking healthy cells are being tested in clinical trials.

At present, countries in AIDS vaccine clinical trials have blocked, will definitely lead to the progressive direction of its R & D focus.

This requires clinical trials in which people who get the test substance are compared with people who do not.

They now wish to develop this compound to a point at which it could be used in clinical trials.

In two other clinical trials still going on, patients taking Vytorin have also been more likely to die from cancer than those not taking it.

The next step will be to confirm these results in macaque [monkeys], the standard model for dengue evaluation before human clinical trials.

The fact that rapamycin is already clinically approved for other uses will facilitate future clinical trials of the drug.

Part of the targeted drug have been entered clinic or clinical trials. Their target and mechanism of action are summarized as follow.

Since the annual mortality of HF is so high, particular emphasis has been put on this end-point in clinical trials.

Preliminary tests have shown that the vaccine is safe, it is to carry out the basic requirements for clinical trials.

Administrators of seven registries in the WHO Registry Network make up the Working Group on Best Practice for Clinical Trials Registers.

Adenoviruses have been used as cancer therapies in clinical trials in the UK but have not yet been licensed.

Many of the patients enrolled in clinical trials have never been treated before and have high serum ALT levels.

Frazier and Mosteller assert that medical research could be improved by a move toward larger, simpler clinical trials of medical treatments.

AIM: To introduce the response-adaptive randomization, which is one of the randomization strategies in clinical trials.

To see the current list of lung cancer clinical trials, visit the National Cancer Institute's site.

The first anti-HIV gel to use a drug known to stop the virus from replicating has been shown to be safe in early-stage clinical trials.

Dr Kirk: We are getting better at it. It is still investigational and we are just now starting to do the clinical trials.

Under the bill, the provision of free drug samples and financing for clinical trials would not have to be disclosed.

If the results are confirmed in clinical trials, heart disease may be a multibillion dollar market for stem cell therapies.

The IHP recommendations aim to standardize the parameters used in clinical trials for lymphoma and incorporate the new technologies.

Additional controlled clinical trials seem justified which may strengthen the power of the meta-analyses.

In addition, a number of "nanopharmaceuticals" are in clinical trials, and a few have already gained FDA approval.

Fisher Clinical Services provides a range of packaging and distribution services for products used in clinical trials.

They point out that moving clinical trials from the United States to an emerging economy could save tens of millions of dollars.

Clinical trials are a long way off, cautions Carmichael, because more animal studies by other labs must be performed first.

Clinical trials of the finished product published by a scientific independent party. (For the new products).

But she warned that a vaccine was likely to be ready only by October because clinical trials would need to be completed first.

The drug is in final clinical trials, and Pfizer management says it has blockbuster potential.

Clinical trials on prepandemic vaccines containing adjuvant suggested that two injections were necessary to induce protective immunity.

An increasing number of engineered protein therapeutics are currently being developed, tested in clinical trials and marketed for use.

The occurrence of oseltamivir-resistant viruses is expected and is consistent with observations from early clinical trials.

This approach will have to prove safe and effective in additional, large-scale clinical trials before it becomes generally available.

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

Clinical trials in which circumcision was performed on a group of adult heterosexual men showed great promise in reducing the risk of AIDS.

Recently drugs that act on cannabinoid receptors- the ones that mediate marijuana's effects- have been advancing through clinical trials.

Newly developed cancer vaccines have been continuously applied to clinical trials, and inspirable results have been attained.

FDA based its approval on two randomized clinical trials of about 125 patients who had received at least one prior ITP treatment.

In the last 13 months, however, the failures of two important clinical trials have thrown that hypothesis into question.

Such clinical trials are the gold standard in terms of determining if a given treatment actually works.

s informed participation in clinical trials, as well as data from all health research disaggregated by sex, at the very least.

In the USA, vaccines for seasonal influenza are licensed without clinical trials on the basis of a "strain change" .

He also plans to apply for a research grant from the US National Institutes of Health to allow clinical trials to be carried out.

Also, China is working with Thailand on clinical trials of a traditional Chinese medicine for HIV treatment.

The findings, reported in the American Heart Journal, build on a phenomenon seen in clinical trials studying heart disease.

They hope to begin animal testing by the end of the year and human clinical trials shortly afterwards.

All previous hypotheses derived from clinical trials, and need to be validated under well-controlled conditions in animal models.

The results of clinical trials on the gel are to be formally released at the 18th International AIDS Conference in Vienna later Tuesday.

A second T-cell-related antibody, which binds to a different immune-suppressing protein, PD1, is being tested in smaller clinical trials.

Responsibilities: - Work with medical manager to design clinical trials, including searching Chinese and foreign literatures.

The two California-based companies are running clinical trials of a drug called ibudilast.

Adrug formulation of resveratrol is now being put to a more rigoroustest, in clinical trials as a treatment for Type 2 diabetes andcancers.

SituGen Ltd. announced the completion of clinical trials of its innovative patent-pending device for the collection of umbilical cord blood.

When it was initially tested in clinical trials, it was found to be toxic in humans.

We really wait with anticipation for the results of these clinical trials.

We have had more late-breaking clinical trials than ever before with lots of new sciences come forward.

Encouragingly , some clinical trials of amantadine used alongside current treatments have improved patients' response.

One example is establishing guidelines for clinical trials, standardisation of traditional medicines and their quality control.

Then those clinical trials ran into trouble when French and German regulators called for a halt to the studies.

Conducting clinical trials for investigational pharmaceutical products is subject to risks and uncertainties.

In November Synthes pleaded guilty to allegations of shipping "adulterated and misbranded" products as part of unlawful clinical trials.

Could you share with us the latest data from the clinical trials on the antioxidant therapy of diabetes and its complications?

Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials.

Dr. Nissen combined the results of many clinical trials to suggest that Avandia substantially increased heart risks.

In clinical trials, the device extended patients' lives by only four and a half months, on average.

Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with localized gallbladder cancer.

Please understand that spinal cord injury clinical trials cost millions of dollars in the United States.

A person familiar with the investigation confirmed that clinical trials were one of several areas the DoJ was examining.

And the foreign clinical trials for children diarrhea are introduced. Finally, paper puts out the subjective factors and herbal treatments.

Unlike traditional clinical trials, they offer multiple different treatments and treatment combinations.

The Committee will continue to review the safety data of new rotavirus vaccines from clinical trials and post-marketing surveillance.

The related content of compensation should be described in the clinical trials contract of the medical devices.

If it passes clinical trials, it will enable women to protect themselves against HIV without approval from their partners.

In order to make this Reference information authentic, traditional clinical trials must be improved to fit to carry out economic evaluation.

Achieving that goal begins with integrated programs in cancer treatment, clinical trials, education programs and cancer prevention.

"The precursor cell type we are using appears to be a good candidate and brings us much closer to clinical trials, " Behie said.

Shea has begun clinical trials to determine whether humans get a similar benefit.

Through the WHO web search portal, people can get a global picture of planned, ongoing and completed clinical trials.

However, despite the successful application in many animal models, the efficacy of DNA vaccines in human clinical trials is unsatisfactory.

This paper introduces the structure, performances and clinical trials of a CPR board.

If a problem didn't come up in clinical trials, they could claim legal or ethical immunity from adverse effects of their drugs.

The aim of this meta-analysis of randomized clinical trials is to assess the effect of rosiglitazone on the incidence of cancer.

France's Sanofi-Aventis SA, meanwhile, is carrying out large clinical trials of an oral MS drug called teriflunomide.

Most of the designer drugs haven't been tested in humans at all, let alone in large clinical trials.

If chemotherapy is selected for palliation, patients should be encouraged to enroll in available clinical trials.

In clinical trials in postmenopausal osteoporosis, PTH administration consistently increased BMD in the lumbar spine and femoral neck.

Merck KGaA Deutschland deploys the Adobe Intelligent Document Platform to optimize clinical trials for new pharmaceuticals.

the NASH CRN project scientist and director of the clinical trials program in NIDDK's Division of Digestive Diseases and Nutrition.

Rider says he hopes to license the technology for trials in larger animals and for eventual human clinical trials.

Hot Line Sessions are reserved for first presentations of the primary endpoint(s) of recently completed clinical trials.

There are no clinical trials that I know of comparing this technology with any other.

This makes pigs ideal for clinical trials of new medicines as well as use in organ transplants for humans.

Short- and long-term therapeutic efficacy of butoconazole vaginal cream was confirmed in numerous high reliability clinical trials.

Thus, clinical trials of a patented medicine will be permitted in the absence of a license from the patent owner.

Researchers also say the study raises concerns about clinical trials used to determine the effectiveness of drugs.

Lastly, clinical trials do not reveal the effects of long-term use.

Multiple clinical trials, requiring intense international collaboration and cooperation will be needed.

Yet there have been only a handful of clinical trials treating patients in the premonitory stage-in part because the symptoms are so vague.

Psychiatrists conducting clinical trials have to ensure that their patients have understood all aspects of the informed consent.

This idea has already sparked off several studies, including clinical trials of vaccines that target cells with high telomerase activity.

Data from these clinical trials will be indispensable to the researchers and developers of emerging and future microbicide candidates.

Sharp disagreement over this issue has surfaced in recent debates over revisions to international guidelines on clinical trials.

WHO believes that the registration of clinical trials is a scientific, ethical and moral responsibility.

Its pharmacodynamic and pharmacokinetic profile, clinical trials and adverse reactions were reviewed in this paper.

Currently, there are several hundred registers of clinical trials around the world but little coordination among them.

Background: The elderly are often excluded from clinical trials of NSTE-ACS and are underrepresented in clinical registries.

Biomarkers can also be used to identify appropriate patient groups for clinical trials.

Many scientists from other institutes then joined efforts to improve the extraction procedures and conduct clinical trials.

They have already grown the bladder, urethra and windpipe which have been implanted into patients during clinical trials.

The clinical trials for cancer are being overseen by Dr. Mace L. Rothenberg, an oncologist recruited this year from Vanderbilt University.

This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results.

Such a marker would also benefit the organisers of clinical trials.

results of bioequivalence tests (clinical trials conducted in healthy volunteers), unless waived.

Clinical trials indicate that acupuncture treatment for melasma has reliable efficacy and less adverse reactions.

Besides the clinical trials, the investigators are working on creating easy-touse formats of the biosensor.

Both the animal experiments and clinical trials have shown that edaravone is effective in the treatment of ischemia-reperfusion injury.

AIM: To enhance management and efficiency of clinical trials, reduce the clinical trial cycle, waste drug, and insure the quality of trials.

Over the years Dr Ernst and his group have run clinical trials and published over 160 meta-analyses of other studies.

The clinical pharmacology of tiotropium and results from published controlled clinical trials are reviewed.

Older women are frequently under treated with adjuvant chemotherapy and are underrepresented in clinical trials.

Locate mental health services in your area, affordable healthcare, NIMH clinical trials, and listings of professionals and organizations.

Ethicists say the case demonstrates the need for more comprehensive regulatory oversight of clinical trials.

Clinical trials are research studies in which people help doctors find ways to improve health and cancer care.

Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

Both of these therapies are slated for human clinical trials.

Participate in organization and implementation of registration tests and clinical trials.

Safety, efficacy and immune routes of influenza VLP vaccine still need for further studies and verification of clinical trials.

The world's first artificial pancreas controlled by the patient's own body has begun clinical trials, researchers announced last night.

The first phase of clinical trials of the main tests of the vaccine immune response, and to further confirm their safety.

Of course, whether these translates to similar effects in humans, only extensive clinical trials can ascertain.

Was the H1N1 vaccine subjected to the same testing and clinical trials as seasonal flu vaccine?

At present, nine clinically approved Mabs are used in the treatment of human cancer, and many others are in clinical trials.

Tuesday, groups that coordinate clinical trials of cancer drugs held a conference call to try to figure out how to deal with the situation.

Prospective clinical trials are needed to guide effective treatment decisions for these patients.

To this end, they are part of sub-Saharan Africa AIDS has a high incidence of oral liver oil capsules for the large-scale clinical trials.

Exercise Therapy and Low Back Pain: Insights and Proposals to Improve the Design, Conduct, and Reporting of Clinical Trials.

An injectable synthetic substance, in Phase 3 clinical trials in India, sabotages sperm as they leave the testes and lasts for years.

A passive immunization treatment developed by Elan Corporation has already advanced to phase II clinical trials.

The ultimate goal is to move these findings to Phase I clinical trials for patients with liver cancer.

However, there is a need for better-designed clinical trials comparing arthroscopic debridement to established alternative treatments.

Clinical trials have shown the vaccine to be both safe and effective in males.

Objective To discuss the clinical trials of using swelling anesthesia periareolar incision to treat persistent pubertal gynecomastia.

Additionally, new side effects, not previously reported in clinical trials, become apparent.

With the exception of cryptococcal meningitis, data from controlled clinical trials supporting such combinations are sparse.

In the 1960s, when beta blockers went through clinical trials, the modern pharmaceutical industry was still in its infancy.

There are, however, no prospective, randomized clinical trials establishing an optimal nonoperative treatment protocol.

Clinical trials have shown that laboratory aspirin resistance is correlated with vascular events.

Clinical trials are checking its safety and effectiveness for colon cancer, psoriasis, and Alzheimer's disease.

Dentists will only need to swab SMaRT, now in clinical trials, onto teeth once to keep them healthy for a lifetime.

CHICAGO - CLINICAL trials for the new swine flu vaccine have turned up no red flags, US health officials said on Friday.

However, most clinical trials conducted with these agonists as monotherapy in patients with cancer have not shown a benefit.

The information contained in the EU Clinical Trials Register is extracted from EudraCT, the EU clinical trials database.

The team then started to organise a set of clinical trials of personalised treatments for lung and breast cancer.

The randomised, as Ms Duflo and her comrades are called, liken their studies to the clinical trials that prove the efficacy of new drugs.

African scientists contributed to the design of study protocols and conducted the clinical trials.

Clinical trials are underway in HIV patients of zinc-finger nucleases that remove a gene that allows the virus to enter immune cells.

He added that other clinical trials are needed to demonstrate fingolimod's efficacy against drugs other than Avonex.

Controlling over adverse events is a key link of clinical trials with major importance for new drug trials clinically.

An extensive review of the clinical trials that have evaluated each treatment is also presented.

Of course, the FDA will still need to maintain a rigorous regulatory process, particularly when it comes to managing clinical trials.

If there are clinical trials in the future, if I was eligible for them I'd be very interested in participating.

Randomized clinical trials(RCTs) results are the sources of evidence.

The FDA requires clinical trials for the riskiest devices through its pre-market approval process.

She says clinical trials of vaccine candidates are going on in China, Australia, the United Kingdom, Germany and the U.

WHO's role in gathering information on the safety profile of candidate pandemic vaccines from clinical trials should be enhanced.

In the US, a handful of cancer research institutions pay for bone marrow and white blood cells as part of clinical trials.

c. Maintaining tissue perfusion in high-risk surgical patients: a systematic review of randomized clinical trials.

Clinical trials involving children require careful ethical review and approval.

Objective: To assess the integrity and quality of informed consents from clinical trials and researches.

Preliminary success has been achieved in application of ex vivo expanded hematopoietic cells in animal model and clinical trials.

Conclusion The safety and efficacy evaluation of this kind of drugs based on the reasonable choice of clinical trials.

Aileron, which holds patent rights from Harvard and the Dana-Farber Cancer Institute, hopes to start clinical trials next year.

Rubber condoms for clinical trials - Measurement of physical properties.

They also note that controlled clinical trials are costly, time-consuming and sometimes unethical.

It will also aim to increase capacity for clinical trials and vaccine manufacture, and to implement ethical and regulatory frameworks.

Many new treatments, including cancer vaccines and gene therapy, are being studied in clinical trials.

Thus, if the drug calms the mutant mice, the team could soon start clinical trials in people with the syndrome.

Reassured, the N. C. I. gave the go-ahead for clinical trials of endostatin later this year on patients with advanced tumors.

The only way we will find out how promising genistein is will be from conducting clinical trials.

To rule out the placebo effect and subjective bias, we must be rigorous clinical trials.

Further more, the compound was studied in two clinical trials in subjects with mild to moderate AD over 24 weeks.

Time will tell, since clinical trials have now started for patients with lung, prostate, and cerebral tumors.

Clinical trials to test the safety and effectiveness of their converted blood are being planned.

These patients may then qualify to participate in clinical trials for medications that treat Alzheimer's.

In the last few years, significant advances have been made in the clinical trials about gene therapy worldwide.

The tests are the first step in human clinical trials of two vaccine candidates developed at the University of Cape Town.

The research must be replicated in clinical trials down the road and tested in other kinds of honeys, Cooper says.

Hershfield developed a new uric-acid-lowering drug called pEG-Uricase, which is now in clinical trials.

Although numerous studies have been promising, there are scant data from randomized clinical trials.

The use as pre- or peri-operative treatments in particular has been validated by several recent clinical trials.

Further clinical trials using biologic agents are warranted to prolong the survival in HCC patients.

Since then, several clinical trials have shown the efficacy of ARVs in preventing transmission to the infant while breastfeeding.

Several clinical trials sponsored by MinsterPharmaceuticals, however, have yielded disappointing resultsso far.

It completely blows cold randomised clinical trials, which don't take into account expectation.