telomere

Their first observation was that, adjusted for age, the telomeres of men and women were the same length.

The test works by measuring the length of the telomeres and is able to then determine the biological age of a person.

'Just as you get your cholesterol or your blood pressure measured, you'd get your telomeres checked. '

One set of Mrs. Young's DNA will be sent to Dr. Blackburn's lab, where the length of its telomeres will be measured.

Our DNA is carrying chromosomes and at each end of these, a sort of protective caps called telomeres.

The results suggest that some people may be genetically predisposed (nature) to age faster, at least as far as telomeres are concerned.

This was the first link between the molecular biology of telomeres and cellular senescence, the aging and death of cells.

The discovery was that the telomeres are actually connected together.

These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.

Later, Ms. Blackburn and Ms. Greider discovered the substance in the body that builds telomeres. The scientists named the enzyme telomerase.

After a cell has grown and divided a few dozen times, the telomeres turn on an alarm system that prevents further division.

The scientists measured the length of telomeres, the tails on the ends of chromosomes, in sample groups in the Glasgow area.

So, it's not certain, but it may be that the beneficial effects of exercise on telomeres really occur via these proteins.

After about 60 divisions, the telomeres are eroded away to the point that the cell stops dividing.

Each time a cell replicates itself (as it does before it dies), the telomeres shorten, like plastic tips fraying on the end of shoelaces.

Why would running or high-level fitness increase the length of the telomeres in the blood?

Telomeres aren't the only reason we age, likely accounting for 10% or less of the aging process, biologists say.

Telomeres, the DNA-protein complexes located at the end of linear eukaryotic chromosomes, are essential for chromosome stability.

In theoretical cancer cells, researchers blocked the telomerase enzyme before radiation treatment to induce progressively shorter telomeres.

As people age, telomeres become shorter. But the scientists found that women with higher vitamin D levels tend to have longer telomeres.

The answer lies at the ends of the chromosomes - the telomeres - and in an enzyme that forms them - telomerase.

Telomeres protect the genes, much like the plastic tips on the ends of shoelaces.

Interestingly, because telomeres and gene promoters are G-rich sequences, they are able to form the G-quadruplex structures.

'To a lesser extent, our study also found that unmarried, widowed, or single older adults had shorter telomeres. '

They targeted the chromosomes that reside within the nuclei of all cells, and specifically telomeres, caps at the tips of chromosomes.

Until now, telomeres have been considered to be transcriptionally silent.

This enzyme repairs and lengthens telomeres, tiny protein complexes on the ends of chromosomes that are vital for immunity and longevity.

The team also found that the protective "caps" on the animals' chromosomes, called telomeres, showed less deterioration.

If you make cells immortal by allowing them to replenish their telomeres, you may raise the risk of many nasty cancers considerably.

Short telomeres have been linked to the incidence of cancer, particularly among white and Asian people.

research suggests TA-65 may help lengthen telomeres on immune cells, the company says.

The results showed that people with lower educational attainment had shorter telomeres, indicating that they may age faster.

Now her creators have determined that the "Caps" on Dolly's DNA that regulate a cell's life span called telomeres are shorter than average.

Most of the cells in our bodies contain long molecules of DNA called chromosomes that have protective caps at either end called telomeres.

When telomeres drop below a critical length, the cell can no longer divide properly and eventually dies.

And we are also seeing that some individuals can maintain or even increase the length of their telomeres over time.

They exposed the cells to ionizing radiation and analyzed DNA repair responses as telomeres became progressively shorter.

These sections - called "telomeres" - cap chromosomes, protecting them from damage.

Telomeres naturally shorten as cells divide, and shortened telomeres are associated with the effects of ageing.

That enzyme keeps cap like structures called telomeres on the ends of chromosomes from getting shorter with each round of cell division.

Telomeres are protective strips of DNA that form tiny 'caps' on the ends of chromosomes, protecting against ageing processes.

The Telomeres tend to become shorter over a person's lifetime, indicating the speed of the ageing process.

Telomeres are sequences of DNA at the end of chromosomes that tend to get shorter every time a cell divides.

Cells age as telomeres get shorter, and conversely, they don't age when telomerase activity is high and protects telomere length.

Women living with stress of having a sick child are found to have shorter telomeres.

Aerobic exercise may also increase the activity of telomerase, an enzyme that repairs telomeres.

the tips of our chromosomes - called telomeres - become shorter.

The length of my telomeres.

Telomeres naturally shorten with aging and are associated with many diseases of aging, including cancer.

The telomeres of most eukaryotes contain short, simple repeats that are highly conserved.

The scientists named the enzyme telomerase. Their research showed that cells age if telomeres are shortened.

Ms. Blackburn and Mr. Szostak discovered the special system of genetic information in the telomeres that protects the chromosomes from ruin.

Short telomeres and low levels of telomerase signal an increased risk of heart disease and cancer, plus a poor prognosis if you do get ill.

Normally, in adult cells the activity of the enzyme is shut off, and telomeres shorten as aging occurs.

When telomeres become critically short, cells stop functioning properly.

Chromosomes carry the genetic information. Telomeres are buffers.

This showed that exercise has a similar effect to counselling on the telomeres of the stressed.

Found on chromosomes in both cancerous and normal cells, telomeres areanalogous to plastic caps that keep shoestring ends from unraveling.

A. Telomeres are the protective caps at the ends of chromosomes in cells.

In the outside world, men generally have shorter telomeres than their female contemporaries.

Greider and Blackburn identified an enzyme, telomerase, that makes the telomeres.

Every time a cell divides, the telomeres shorten, like plastic tips fraying on a shoelace.

While telomeres themselves are DNA, there are also important proteins that bind to telomeres and stabilize them (mentioned above).

Their research suggests that stress management not only stops telomeres from shortening, it actually promotes their repair.

Longer telomeres indicate low levels of inflammation, he explained.

Many studies have shown telomeres get shorter over time, suggesting the cells are ageing or dying.

Telomeres are structures at the ends of human chromosomes that protect DNA from damage.

Every time a cell divides, its telomeres get shorter, and once a cell runs out of telomeres, it can't reproduce anymore and dies.

Shortened telomeres have been linked to a host of age-related illnesses such as heart disease and certain cancers.

In the 1980s they showed how telomeres, distinctive caps on the ends of chromosomes, protect a living cell's DNA and genes from degradation.

But each time the cells divide, telomeres get shorter.

Elizabeth Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation.

He says the work of telomeres is important to the understanding of how genetic material is copied and saved.

Leukocyte telomeres shorten over time and may serve as a marker of a person's biological age.

Blackburn shared the 2009 Nobel Prize for physiology or medicine for discovering telomeres and telomerase.

Research shows that individuals with shorter than normal telomeres have a shorter life span than those individuals with longer telomeres.

Telomeres are the latest buzzword in medicine.

12 Telomeres, sequences of DNA at the tips of chromosomes, get shorter every time a cell divides; when they get too short, the cell dies.

Telomeres, the specialized structure of chromosomes ends, consist of tandem arrays of DNA repeats and related proteins.

The tips of chromosomes, called telomeres, shorten every time a cell divides.

Telomeres are necessary for a cell to divide.

Each time a cell divides, its telomeres get shorter until a critical points reached.

If the telomeres did repeatedly shorten, cells would rapidly age.

Blackburn and Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation.

Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk.

that maybe progeria patients just have very short telomeres.

When cells divide, telomeres gradually become shorter and the cells age.

When the telomeres become very short, the cell starts to malfunction and show signs of ageing.

Their research showed that cells age if telomeres are shortened.

She says without telomeres, the chromosome and the genes it holds would come apart.

She says without telomeres the chromosome andgenethegenes it holds would come apart.

For now, the link between shortened telomeres and aging is tenuous at best.

What role do telomeres and centromeres play in genome function?

Here, we show that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres.

Telomerase is an enzyme that can rebuild and lengthen telomeres.

When our telomeres are healthy, our cells remain healthy.

In the Danish study, the more fresh-faced people had longer telomeres.

She says without telomeres the and the genes it holds would come apart.

and every time our cells divide, our telomeres get short.

Every time a cell divides, its telomeres get shorter.

If the telomeres are shortened, cells age.

Shortening and gradual loss of telomeres hold back cellular proliferation.

Cancer cells have the ability to keep on dividing without suffering chromosome damage because they preserve their telomeres.

Typically, someone aged between 41 and 50 will have about 23 per cent of their telomeres categorised as short.

The caps, called telomeres, are made from copied strands of DNA and have a similar function to bookends or the plastic ends of shoelaces.

How did you get interested in telomeres?

Telomeres are enzymes that regulate how many times an individual cell can divide.

The study, which extracted a DNA sample from their volunteers, found people who exercised more each week had longer telomeres.

This means they are born with shorter telomeres, and so are prone to ageing more quickly.

In the study, the people who looked younger had longer telomeres.

Scientists have yet to study whether telomeres influence a person's appearance.

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effects can occur at telomeres and centromeres, which