telomere

But a bad result can act as an alarm call, she says. Better to act after a telomere test than to wait for your first heart attack.

It concluded: 'The state of being married was the only significant predictor of telomere length when all other factors were not adjusted. '

Moreover, it was not merely the father's telomere length that correlated with that of his offspring, but also his actual lifespan.

One of these anticancer barriers is the telomere, a specialized nucleoprotein complex that caps the ends of eukaryotic chromosome.

Telomere length was as good as cholesterol levels at predicting the risk of developing cardiovascular disease.

Here mainly to explain the mechanism of premature senility, decided life of cells as a key material -- chromosome ends of the telomere.

Some scientists are trying to extend life by extending the telomere.

The "hand" is the last 100 to 200 bases of the telomere, which are single- stranded , not paired like the rest.

Genetic factors and environmental stressors can shorten the length of the telomere.

Measuring telomere lengths definitely has a proven value if you want to compare thousands of people at a time.

Initial observations suggest that cellular senescence is the result of telomere shortening.

Telomere lengthening was even greater if the child's paternal grandfather had also been older when he became a father.

Mitochondrial DNA(mtDNA)and telomere are the primary DNA markers used in deducing individual age in recent years.

With the occurrence of genetic mutations the cells can continue to grow even though their telomere continue to be shortened.

With that in mind, the researchers started comparing telomere lengths within families.

Each segment of a telomere is like a ticket that gives it permission to divide.

'The relationship between income and telomere is not accounted for by physical diseases, mental state and neighbourhood experience.

The tips of all chromosomes are covered with a very special DNA sequence, in a region called the telomere.

Conclusion: Shortening of telomere may be one of pathomechanism of spleen Qi deficiency syndrome.

Variations in telomere length have been reported in severe aplastic anemia but their clinical significance is unknown.

His work showed that the inability to add nucleotide repeats to chromosomes led to telomere shortening and eventually cell death.

The study of telomere length in peripheral white blood cells of patients with coronary atherosclerosis and its significance .

But he concedes: 'Telomere tests might become commonplace, but probably not the tests we have now. '

Telomere is synthesized with the action of telomerase, a ribonucleoprotein with reverse transcriptase activity.

The mean telomere lengths in the normal gastric mucosa, precancerous lesions, gastric cancer and metastatic carcinoma gradually shorten.

It gave us great confidence that we identified genetic variants on a pathway we already know is associated with telomere length.

Measure "telomere" in length and tested, you can come to a human "biological age" compared with the actual age.

Can telomerase and ALT both be eliminated without deleterious effects on the cell or tissue that are independent of telomere length?

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity.

At a critically short telomere length, however, a so-called crisis occurs, with imbalance in the genes and massive cell death.

What he found surprised him. Not only did counselling stop telomere shrinkage, it actually promoted telomere growth.

Objective: To investigate the relationship of expression level of telomere binding factor with the degree of malignancy of hunan gliomas .

TERC is likely only one of several genes that influence telomere length, says Tim Spector of Kings College London, who co-led the study.

Sure enough, the data indicated that higher levels of circulating vitamin D was associated with longer telomere length.

Cells age as telomeres get shorter, and conversely, they don't age when telomerase activity is high and protects telomere length.

Telomere length was inversely correlated with the probability of disease relapse.

In addition, estimating age of humans based on telomere shortening will display enormous applicational prospect in forensic medicine.

Telomere length and telomerase activity are important factors in the pathobiology of human disease.

The measurement of telomere length can give an insight into the replicative history of the cells in question.

Telomere plays an important role in maintaining the stability of intact chromosome, genome and cell.

Telomere is a special structure exsiting at the end of chromosome whose length is related to the cells duplication and decrepitude.

Telomere shortening is the early event of gastric cancer.

The correlation between paternal lifespan and children's telomere length applied only to daughters.

However, they did find that telomere length in the runners' quads was inversely related to the amount of running they had done.

Can we rely on telomere-depleted stem cells removing themselves by differentiation?

I was the first to show an association between blood telomere length and age-related disease.

Each time a cell divides, the telomere is shortened. When the telomere gets too short, the cell stops dividing.

Researchers estimate that telomere maintenance activity occurs in about 90% of human cancers.

How about habits or routines believed to shorter telomere lengths.

But what's the advantage of knowing your telomere length?

The mechanisms of NBS1 in DNA damage response and maintenance of telomere stability are reviewed in this paper.

Not only did counselling stop telomere shrinkage, it actually promoted telomere growth.

But if the telomerase enzyme is very active, telomere lengths are maintained and cells are kept young.

Telomere and telomerase play important roles in the process of cellular senescence.

Telomere protein expression may be working together to reduce the telomere length, thus promoting the development of gastric cancer.

This way, you lose telomere material during cell division, rather than important coding DNA.

Our second chromosome has telomere DNA at the center.

Telomerase is a kind of ERT which causes catalysis and prolong the end of telomere.

In this way, the telomere acts like a biological fuse.

Telomerase is a ribonucleoprotein that is responsible for maintaining telomere length.

"Telomere length is more reflective of things that happen in your life than the genetic hand you are born with, " said Dr. Blackburn.

Q. Is there a link between telomere length and stress?

Do I think it's useful to have a bunch of companies offering to measure telomere length so people can find out how old they are?

I went to the one place in the world that offers a telomere test to patients: Life Length, based in Madrid.

overall , the study participants had an average telomere loss of 21 nucleotides ( structural units ) per year.

The researchers found that obese women aged an additional 8. 8 Years more than lean women (based on telomere length).

These assays can be used to study the in vitro cellular effects of aging and cancer treatments on telomere biology and telomerase activity.

To study the biological basis of selenium in resisting senescence through its effects on cellular telomerase activity and telomere length.

The quantificational relationship between the length of telomere DNA and age in peripheral blood leukocytes

Measurement of telomere length of intercapillary cells by real - time quantitative PCR

A Digoxin-Labelled Method to Measure the Length of Telomere Restriction fragment of Human Chromosome

Alteration and significance of telomere length of peripheral white blood cells in patients with type 1 diabetes mellitus

Influence of captopril on length of mice cardiac fibroblast telomere;

The last advances in study of telomere and telomerase

Relationship between radiosensitivity of human squamous carcinoma cell lines and changes in telomerase activity and telomere length

Correlations of Telomere Length and Telomerase Activity to Radiosensitivity of Human Laryngeal Squamous Carcinoma Cells

Research Progress of Relationship between Telomere, Telomere Relating Proteins and Cell Senescence

Mapping genetic Loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs

Establishing molecular age anatomy--the valuable application of telomere length measure in forensic medicine

The Relation Between Telomere, Telomerase and Tumour and Its Applications

A nonradio-labelled method assays to measure the telomere length of human chromosome

Detection of telomerase activity using telomere repeat amplification protocol-microtiter plate hybridization

DNA demethylation leads to telomere shortening with accelerated aging process in human diploid fibroblasts

Correlation of Telomere Length and Radiosensitivity in Human Laryngeal Squamous Carcinoma Cells

Shortened telomere length in peripheral lymphocytes of patients with autoimmune thyroid disease

Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis. Effects of telomeraseand oxidative stress

Significance of Telomere Enzyme Activity Detection by Paraffin-embedded Sections of Mammary Cancer

Relationship between Radiosensitivity and Telomere Length in Human Carcinoma Cell Lines

Telomere and telomerase reprogramming in early mammalian embryo development

Progress in research about the relation between telomere, telomerase and cervical cancer, precancerous lesion

The role of telomere, telomerase and its hTR in nasopharyngeal carcinoma

Telomere length and hTERT expression in carcinogenesis of esophageal epithelium

Telomere shortening in the pathogenesis of nasopharyngeal carcinoma

Relationship between apoptosis and telomere length in rabbit retinal ganglion cells

The significance telomere length and telomerase activity in salivary gland neoplasm

Differential Diagnosis Value of Telomere Ferment Activity to Benign and Malignant Ascites

Analysis of telomerase activity and telomere length in acute myelogenous leukemia

Experimental Study on the Change of Telomere Length in the Liver of Rat Model with Spleen Yang Deficiency syndrome

Telomere and telomerase activity changes in mylodysplatic syndromes with disease progression

Telomere-shortening is an absolute problem that we have

Mechanism of telomere maintenance dependent on telomerase

The Relationship between Oxidative Stress and Telomere on Telomerase

Detection of telomere length in esophageal squamous cell carcinoma tissue

Cloning and sequencing of Telomere-associated Sequence in Chicken Tissues

Dynamical equation of chromosome telomere in cellular automata

Telomerase activity and telomere dynamics in colonic carcinoma

Detection of telomerase activity and telomere length in kidney cancer tissues

the common role of genomic instability; the biology of the telomere;

Telomere and Telomerase in Spermatogenesis

Research on Telomere Length in Hepatic Tissues of Rats with Spleen Yang Vacuity Pattern

Telomere, Telomerase and Hematopoietic Stem Cell

Effect and Mechanism of Selenium, Zinc and Lead on Cellular Telomere and Telomerase

A new strategy of malignant gene treatment taking telomere and telomerase as target(A review)

Telomere as a potential anticancer target

Ability of eliminating active oxygen and the changes of DNA telomere length in aging mice and the interventional effects of huanshao dan

Analysis of telomere length in normal gastric mucosa from donors of different ages

Application of Telomerase and Biology of Telomere in Medicine Field

Telomere and Telomerase Activity of Neural Stem Cells Cultured in vitro

Research progress on telomere binding proteins

The Application of Telomere DNA in Age Estimation of Forensic Medicine

Research Progress on Structure and Functions of Telomere

Mechanism of Telomere Maintenance and The New Strategy for Cancer Therapy

Study on the Telomere and Telomerase and their Application in Tumor

Study on telomere lengthening induced by radiation

The Biological Property of Telomere and Telomerase

Estimation of human age according to telomere shortening in peripheral blood leukocytes

Progress of Telomere and Telomerase in Higher Plant

Variation of telomere length in human lymphocytes caused by oxidative stress

An improved method to quantify telomere

Telomere and Telomerase--A New Juncture for People to Surmount Cancer

Progress in the study of telomere and telomerase

telomere of yeast is rich in g and a that is ideal target of mms

The development of research on correlation of mitochondrial DNA and telomere with individual age

Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy

A Study on the Association of Telomere Length with the Experimental Carcinogenesis of Oral Cavity