tnf-?

The FDA also reviewed 69 cases of psoriasis and said it found a possible link between the skin disorder and use of TNF blockers.

B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte.

And one of the things were looking at is specific phosphodiesterase inhibitors to block the endotoxin or LPS-stimulable TNF.

The FDA said it had reviewed 147 reports of leukemia in adults and children using TNF blockers, including 30 deaths.

The second report links susceptibility to SLE with increased expression of a gene in the tumor necrosis factor (TNF) superfamily .

These cells are activated by a chemical compound called tumor necrosis factor (TNF) released by the neutrophils.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily .

Patients who develop a fungal infection may be advised to stop the TNF blocker until they recover.

TNFR-specific effects in HF should be considered when therapeutic anti-TNF strategies are developed.

The FDA also has received reports of cases of coccidioidomycosis and blastomycosis, including deaths, in patients treated with TNF blockers.

Patients taking TNF blockers should be aware that they are more susceptible to serious fungal infections.

In this chapter, we give an introduction to the different TNF antagonists, with the main focus on therapy management and safety issues.

Among the three anti-TNF-alpha agents, this phenomenon has been studied mainly in patients using infliximab, especially in RA and CD.

Remicade belongs to a class of drugs called tumor necrosis factor (TNF) blockers.

Cathepsin B actively participates in hepatocellular apoptosis, e. g. after exposure of hepatocytes to TNF .

Results. Typical apoptotic changes of the cell nuclei were observed in the DRG after application of TNF.

Overproduction of a cellular messenger called TNF (tumor necrosis factor) is believed to play a role in psoriasis.

Research Design and Methods: RIP-TNF-NOD mice were crossed to B cell deficient NOD mice and diabetes development monitored.

The scientists showed that all three drugs inhibited the production of TNF, which reduced inflammation in these cells.

Death receptors belong to the tumour necrosis factor (TNF) receptor superfamily.

thus , we also investigated the effects of elf - mf exposure on clustering of egf , tnf receptors in cultured cells.

inflammatory and remodeling responses in HF that are TNF-receptor (TNFR) specific.

Immunosuppressive drug addiction can reduce the induction of anti-TNF-alpha antibodies.

Objective: To explore the changes of thyroid hormone and tumor necrosis factor(TNF) in severe patients.

We identified the generation of amino-terminally truncated versions of DBC-1 during tumor necrosis factor (TNF)--mediated apoptosis.

Conclusion: TNF may play an promoting role in eccentric left ventricular hypertrophy.

Expression of TNF-[alpha] was compared in rats with crush injury, with and without sympathectomy.

Etanercept is a recombinant soluble TNF-alpha receptor fusion protein that binds to TNF-alpha.

Conclusions There is some evidence, albeit incomplete, that combination therapy using TNF-inhibitors is most effective.

There are now a few uncontrolled studies supporting the use of TNF inhibitors in patients with active disease.

Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease -- or both?

These results suggested that the TNF played an important role in the pathogenesis of MWA.

Unfortunately in humans, wiping out all the TNF is not good, which is what Etanercept does.

Editorial: Anti-TNF Treatment in Crohns Disease: TowardTailored Therapy?

But does anti-TNF therapy do anything to reduce the incidence or severity of ankylosis?

RESULTS Ning Zhi Ai can increase their NK activity and decrease their TNF activity.

TNF Antagonists Reduce Cardiovascular Deaths in Rh.

The presence of single-stranded DNA, Caspase 3, and TNF further confirmed the occurrence of DRG cell apoptosis.

The injectable drugs suppress the immune system by blocking the activity of TNF, a chemical that can cause inflammation.

Conclusions: RDQ has the inhibitory effect on the production of TNF induced by endotoxin.

As far as biologics go, I tend to use either an anti-TNF or Raptiva (efalizumab) before alefacept.

Objective To determination the serum interleukin-12(IL-12) and tumor necrosis factor (TNF) in patients with viral hepatitis.

TNF and insulin levels were highly correlated.

Methods The serum TNF were measured by ELISA method in 50 patients with atherosclerosis and 15 health cases is control subjects.

Results With aging, levels of serum E2 and ER of splenic cells and IL - 2 and TNF activities decreased progressively in female rats.

Instead a better rational is to decrease the excess production.

Sales of the TNF-alpha blockers have more than tripled since 2002, according to IMS Health.

Numbers of TNF-[alpha]-immunoreactie cells were significantly increased at days 1 and 3 in the arthritis group compared with controls.

Cytokines such as TNF may prevent transcription of the thrombomodulin gene.

In addition, anti-TNF treatments may blunt this effect in AS patients.

Method Serum level of TNF and STNFR were detected in 26 cases of urinary bladder carcinoma and 20 normal subjects as controls.

It can neutralize the bioactivity of TNF and inhibit the killing effect on cells.

Investigators focused on gene TNFSF4 (TNF superfamily member 4) and the receptor gene TNFRSF4, both on chromosome 1.

TNF-related apoptosis-inducing ligand receptor-1 and -2 (TRAIL-R1 and -R2) are also present on hepatocytes.

Objective To study the relationship between nitric oxide(NO), tumor necrosis factor(TNF) and acute pancreatitis.

Objective To study the clinical significance of determination of serum TNF and IL-8 levels in patients with ovarian cancer.

Objective To study the changes of serum TNF and SA in patients with rheumatic arthritis.

Objective To study the clinical significance of determination of serum TNF and IL 8 levels in patients with lung cancer.

Aim To study the effect of pseudomonas aeruginosa-MSHA vaccine on level of serum tumor necrosis factor (NTF) in hepatic fibrosis.

Relationship between serum TNF, interleukin - 8 and cause and course of disease in the children with bronchopneumonia with gasp

Establishment and application of a cell model for screening neutralizing monoclonal antibody against human TNF

Expression and Purification of Secreted form TNF-related Activation-induced Cytokine in E. Coli as a Maltose-Binding Protein Fusion

Effects of Two Different Regimens of Pulse Cyclophosphamide on Clinical Activity and TNF Levels in Lupus Nephritis

Changes of Inositol Lipid Signal System and Its Effect on the Secretion of TNF of Peritoneal Macrophage Following Severe Scald in Mice

Therapeutic and preventive effect of dexamethasone on endotoxin shock in rabbits and its relationship with TNF

Myocardial TNF content and mitochondrial stereology in patients undergoing mitral valve replacement at beating or arrested heart

Cloning, expression, purification and biological activity assay of TNF-related apoptosis-inducing ligand

Changes of TNF in the early stage of cerebral edema following severe burn and their significance in dogs

The Relation Between TNF Microsatellite Loci Polymorphism and Systemic Lupus Erythematosus in Yunnan People

Effect of the Method of Tonifying Kidney and Promoting Blood Circulation on TNF and SOD in Endometriosis-Associated Infertility

Result: After standardization in age and insulin, serum TNF still affected the blood glucose and insulin levels of X syndrome patients;

Preliminary analysis on relationship between the TNF secretion in rat macrophages and the LPS dose

Clinical significance of pre - and postoperative peripheral blood NK cell and TNF in patients with colorectal carcinoma

Study on recombination human soluble TNF-related apoptosis-inducing ligand pilot-scale purification

Dynamic changes of TNF and Captopril Intervention during myocardial ischemic reperfusion

Experimental study on apoptosis of osteosarcoma cells induced by TNF-related apoptosis-inducing ligand

Expressions and Functions of TNF in Sera of Rabbits After Acute Extremity Ischemia Reperfusion and Pretreatment

Clinical Significance of Determination of Changes of Serum TNF and SA Levels After Treatment in Patients with Gonorrhea

Radiometric Analysis of Recombinant Human TNF Receptor-Fc Fusion Protein in vitro and the Relation between Analysis and Activity

Significance of determination of TNF in amniotic fluid in early diagnosis of bacterial infection of amniotic cavity

Expression of Recombinant GFP-TNF Fusion Protein and Its Application

The Interruption of TNF Monoclonal Antibody on Muscular Protein Hypercatabolism after Scalding in Rat

the rise in TNF-alpha activates microglia , cells that comprise part of the eye's immune system;

The effect of anti-TNF-mAb on the apoptosis of myocardial cells during the continuous ischemia and ischemia reperfusion injury

Expression of TNF related apoptosis inducing ligand in peripheral blood mononuclear cells

Levels and significance of TNF-a in peripheral blood and synovial fluid form patients with rheumatoid arthritis

Psychosocial aspects and changes of TNF content in the patients with recurrent spontaneous abortion

The Protective Effects and Mechanism of TNF on Mycobacterium Tuberculosis Infected Mice

Effect of TNF- related apoptosis inducing ligand on the biological activity of hepatocarcinoma cell line

Clinical significance of detecting serum TNF and SA from patients with rheumatic arthritis

Influence of Ischemic Preconditioning on Apoptosis of Myocardium and TNF Plasma Level

Study of serum TNF, IL-6 levels in patients with coronary heart disease a nd their relationship

Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29

Changes of TNF - a in Liver Cirrhosis Patients with Upper Gastrointestinal Bleeding

Serum endotoxin and TNF levels in patients with malignant obstructive jaundice

The effect of TNF-related apoptosis-inducing ligand on in vivo graft survival after ex vivo adenovirus-mediated gene transfer to cornea

Recent advances for research on anti-tumor effects of TNF-related apoptosis-inducing ligand

Superoxide radicals directly produced from TNF-treated cancer cells

Effects of Cytokines on Secretion of TNF by Glomeruli and Glomerular Mesangial Cells in Vitro

Analysis on Curative Effect of Malignant Hydrothorax Treated with New Recombined TNF

Effects of astragalus on serum and urinary TNF levels in patients with nephrotic syndrome

Effect of TNF-Related Apoptosis Inducing Ligand on Hepatocellular Carcinoma in Mice

The investigation on relationship between levels of TNF in serum of patients with type 2 diabetes mellitus and osteoporosis

The roles of TNF family members in the regulation of osteoclast activity in peri-implant tissues

Clinical significance of determination of changes of serum IL-6, TNF and VEGF levels after treatment in patients with lung cancer

Effect of antibiotics and anti-TNF agent on the serum endotoxin and cytokines in the treatment of sepsis in mice

Detection of TNF and IL-6 in serum of virus hepatitis patients and its clinical significance

TNF Related Apoptosis Induced Ligand and the Receptor in the Apoptosis of Malignant Melanoma

Curative effect of local TNF inoculation for patients with malignant effusion

An experiment on the expression of TNF-a and changes of retinal hemodynamics in diabetic rats

Study on Correlation of Polymorphism of TNF Genes with Pneumoconiosis

A Study of the Changes on IL- 6 and TNF in Workers Exposed to Benzene

Genetic polymorphisms at the TNF locus in Chinese Han population

The influence of glycine on plasma TNF and endotoxin in rats with acute pancreatitis

Changes of PG and TNF in hepatic tissue in aged rats with cerebral ischemic reperfusion

Effect of Mounting Points on the Activity of TNF in Peripheral Blood of Ascites Carcinoma Mice

Effect of walking movement on plasma TNF and receptor in chronic heart failure patients

The effects of TNF on the regulations of glutamine for liver protein synthesis in rats

Effect of nicotine on the secretion of TNF of human peripheral blood mononuclear cells in vitro

Recent Progress in Clinical Application of Anti-TNF Antibody McAb

positive charge; TNF doping at high concentration;

Kinetic Analysis of TNF Immune Complex by Using Surface Plasmon Resonance

TNF related apoptosis inducing ligand, TRAIL

Effects of passive smoking on bone metabolism and plasma TNF level in rats

Effect of glycine on acute necrotic pancreatitis and the contents of TNF-c and endotoxin

Effects of TNF on the apoptosis of prostatic carcinoma cell line

Expression of TNF receptor in human spermatozoa

The effect and mechanism of chuanhuning injection on secretion of TNF in rat alveolar macrophages induced by LPS

Influence of different acupuncture tine on serum IL-4 and TNF levels in sensitized guinea pigs

Recombinant Human soluble TNF Receptor Type II

Study on NK cell activity and TNF secretion of healthy elderly

Measurement of TNF, SA in serum from type 2 diabetes and their clinical significance

Serum level of TNF expression in normal term delivery mothers and newborns

The protective effect of removing circulatory TNF by immunoa-dsorption on endotoxin-induced acute lung injury

Effect of acute lung injury after intestinal ischemia reperfusionin rabbits about TNF IL- 6 Activity

The Effect of Radix Salvia Mitorrhiac Injection on the Blood Serum TNF of Alcoholic Liver Injury Rat

Association of TNF gene polymorphism with Helicobacter pylori infection in Chinese patients with gastroduodenal diseases

Association of tumor necrosis factor microsatellites TNF with the susceptibility to and outcome of postoperative severe sepsis

The association of susceptibility of thymoma and the gene polymorphism of TNF