starting material

The synthetic way showed the disadvantage of commercial available starting material, mild reaction conditions and easy to operate.

The company should document the rationale for the designated API starting material.

Preferably the starting material is dissolved in methanol and a stoichiometric excess of ammonium hydroxide is added.

Q. What is an acceptable mechanism for confirming the suitability of an alternate source of a starting material?

Imidacloprid was synthesized through four steps by the method using 3-methylpyridine as starting material. The total yeild was 43%.

Table 1 gives guidance on the point at which the API starting material is normally introduced into the process.

This GMP Guide does not apply to steps prior to the introduction of the defined "API Starting Material" .

CONCLUSION The phase transfer catalyst has advantages of simple starting material, convenient operations and mild reaction conditions.

Where in a given process the designated regulatory API starting material comes will vary with each process.

The decision to designate an API starting material is based on more than chemical logic. It is a pharmaceutical consideration as well.

Methods: The target compounds were synthesized by multi-step from resorcinol and p-substituted phenylacetic acid as the starting material.

Methods: The target compound was synthesized using substituted aniline as starting material by condensation, hydrolysis and oximation .

If starting material is obtained by fermentation or is from herbal origin, summarise the information related to the nature of this material.

The overall yields of luteolin and robot, calculated from phloroglucinol as the starting material, were 22% and 15%, respectively.

Appropriate qualification of API Starting Material suppliers is required.

advantages include less downtime to charge the reaction vessel with starting material, and less workup.

Crystalline graphite flake is the starting material in the manufacture of expandable graphite.

Ultimately all the starting material is converted into products.

An applicant should provide complete information on the synthesis, from starting material(s) to the bulk new drug substance.

Using fatty alcohol as starting material, double octyl quaternary ammonium bromide was obtained. It's yield reached 80%.

The method based on pyruvic acid or pyruvate as starting material was considered to be the best one.

The starting material for the aluminium tube is a so-called slug, a circular aluminium disc from which the tube is made by impact extrusion.

The heated starting material (1) is continuously molded into the molded article, and the resin is cured in the molded article.

The advancing starting material (1) is heated in passing by applying an alternating magnetic field to the resin.

A starting material including silica and carbon is heated to form an intermediate material.

Q. Could you elaborate on section 12. 6? Would a change in the source of an API starting material require revalidation?

Such approaches are suitable for situations in which large amounts of starting material, such as tumors or brain tissue, are available.

The starting material for producing API from which country?

Q. Is your process validation starting point defined of your choice of your API starting material?

How do you define a "significant structural element" in an API starting material?

Q. How do you define a "significant structural element" in an API starting material?

This sheet is used as a starting material for making cellulose others.

Using 1-pentanol as a starting material, 1-Qeten-3-ol is Synthesized by nucleophilic substitution of HBr, Grignard reaction.

Such as skin color and roll from the starting material identification, as may be a glimpse of 12.

METHODS Ranolazine was synthesized by using 2, 6-dimethylaniline and guaiacol as the starting material fellewed by 4 step reactions.

Let's say we have an abundance of the starting material, and not very much light.

METHODS(1) was synthesized by using 3, 4-dimethoxyphenylacetonitrile(2) and 2-bromopropane as the starting material with selected PTC.

Profibus based control system of starting material processing for refractories applied in thin slab continuous casting

Preparation of 107 adhesive with vinyl acetate as the starting material

Development of High Water-absorption Road Bricks Using Dolomite as Starting Material

How close can you get to the API and still call it an API starting material? API