receptor

One example of a gene that we would like to turn off is an insulin receptor gene that tells fat cells to hold on to every calorie.

The gene affected seems to make a protein that acts as a "receptor" or docking point for nicotine in the brain.

"I thought [such a] receptor can't be making the entire change in the body. There must be other proteins, " Wang says.

While hormone receptor did not change the bimodal pattern of mortality risk, the results showed that it was a time dependent variable.

A substance that can combine with a nerve receptor to produce a reaction typical for that substance.

When he made these 7 changes to the ancestral receptor, it behaved just like a new glucocorticoid receptor.

So this time, Chen's team injected the spinal cords of mice with a neurotoxin that seeks out the GRPR receptor, sort of a docking site.

The major targeted therapy used for prostate cancer is directed at the androgen receptor and it is not always effective, Witte said.

Antigen receptor gene rearrangement and hybridization have been used routinely in auxiliary diagnosis of lymphomas.

Horses are not sensitive taste receptor, therefore, horse gathering a wide range of food, horse is the most easy to raise animals.

His lab hopes to knock out a specific oestrogen receptor in dogs to understand the hormone's effects on fertility.

Flag to write out the coordinates of the receptor into a new, cleaned-up file. Atoms are resorted to put all residue atoms together.

Prior to this study, tamoxifen was used for the treatment and prevention of oestrogen receptor-positive breast cancers, Dr. Pinkerton said.

Most female insects should have this sort of receptor including the kinds that spread disease and devastate crops .

Darifenacin is a selective muscarinic M3-receptor antagonist that has been used in patients with overactive bladder syndrome (OAB).

Each growth factor binds to its own specific receptor, which activates a unique set of signaling molecules.

Meanwhile, Dr Young says that he and his colleagues have found a lot of variation in the vasopressin-receptor gene in humans.

Estrogen receptor modulators, aromatase inhibitor, ovarian ablation are the primary means of endocrine treatment of breast cancer.

Researchers thought this meant the receptor would be central to the survival of those cancer cells, but that has not consistently been so.

Calmodulin, the predominant calcium receptor, is one of the best-characterized calcium sensors in eukaryotes.

That led Dr Forstmeier to ask whether the type of hormone receptor a bird has influences its digit ratio, its sexual behaviour or both.

The virus enters a host cell after part of HA, the receptor-binding domain (RBD), has bound to a specific part of the cell.

It would also be important for treatment and prognosis to determine if these cells were estrogen and progesterone receptor positive.

Therapeutics targeting epidermal growth factor receptor (EGFR) are unable to effectively inhibit tumor growth in a majority of cases.

Sometimes there is interference with this process, such as if the receptor is blocked and unable to receive the neurotransmitter.

Cells that are not targets for the action of a particular hormone or neurotransmitter do not have these receptor proteins.

The invention provides an organic dye with quinoline carboxylic acid as the receptor and a solar cell sensitized by the organic dye.

These findings suggested that HBV-SBP might be a co-receptor mediating hepatitis B virus invasion to hepatocytes.

Moreover, blockade of these transient receptor potential channels can greatly ameliorate the pain response in experimental pancreatitis.

This was caused by an enhanced cellular uptake of the resultant complexes via a receptor-mediated endocytosis process.

Endothelin(ET) is a recently discovered potent vasoconstrictor peptide exerting effects through combination with its receptor.

The endothelin receptor antagonist bosentan is one of the effective drugs for pulmonary arterial hypertension.

Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems.

Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body.

Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.

This hormone (it's not actually a vitamin) has receptor sites in every area of the body including the immune system and respiratory tissue.

This receptor resides in the membranes of many different cells in the body, including macrophages and dendritic cells.

This field received tremendous attention worldwide in terms of developing novel androgen receptor antagonists to combat the deadly disease.

A specialized sensory nerve receptor that receives and responds to stimuli originating from within the body .

A strong association to pre-term births was found in variants of the FSHR - or follicle stimulating hormone receptor - gene.

His tests revealed differences in one site located in a gene for a hormone receptor that may be active in learning and memory.

The reason, Dr. Ambati said, was that the RNA snippets were actually binding to an immune system sentry called toll-like receptor 3.

This protection largely mimics the previously reported effects of a mineralocorticoid receptor antagonist in this experimental model.

The siRNA is selected to target one of the genes responsible for making cancer cells grow quickly, called epidermal growth factor receptor.

The enrichment factors and Chemical Mass Balance receptor model were applied to determine the main sources for PM in the studying area.

Using androgen-receptor as a target may be an effective approach for the treatment of advanced prostate cancers.

To be precise, they have been linked to a hormone called vasopressin and the protein molecule that acts as its receptor.

Leptin receptor deficient mice do not know the feeling of fullness.

However, TRAIL receptor expression on hepatocytes as well as sensitivity to the specific ligand TRAIL is still a matter of debate [5].

Results showed the peptide capable of inhibiting viral attachment to the cellular receptor ultimately preventing infection.

As an apiod receptor antagonist, naloxone used to be a special antidote of meconiums.

AMF and its receptor positive cells began to appear in pyramidal layer in the 17th fetal hippocampus.

A home blood pressure monitoring study comparing the antihypertensive efficacy of two angiotensin II receptor antagonist fixed combinations.

The smell of the upside after olfactory receptor is located in nasal cavity is epithelial inside, experience a cell to be smell cell.

"Future studies with a larger number of receptor-negative and mixed tumours are required" they concluded.

It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs).

CONCLUSIONS Weight reduction with GLP-1 receptor agonists was associated with a shift toward a more favorable cardiovascular risk profile.

The P2Y receptor agonist may be administered with therapeutic and adjuvant agents commonly used to treat edematous retinal disorders.

Immediate-release formulations for oral administration of a thrombin receptor antagonist are provided.

Mifepristone is an antagonist of 1 of the body's 2 cortisol receptors and its progesterone receptor.

Dr Audero's experiment did not manipulate the receptor gene directly but, rather, manipulated its activity using the switch.

An NMDA receptor is like a double-edged sword because too much activity and too little can be toxic.

Aim: To investigate the expression of thyrotropin receptor (TSHR) in differentiated thyroid carcinoma (DTC) tissue and its significance.

For the past few years, study of non-classic actions of aldosterone receptor blocker have been hot spot, especially eplerenone.

Their original experiment used a genetic switch to regulate production of a particular receptor molecule for serotonin.

The receptor has important function on mediating migration, survival, growth and vasculogenesis of the human malignant glioma cells.

Neutralizing antibodies and peptide-receptor antagonists have both been shown to be effective antagonists in vivo .

Myasthenia gravis(MG) is an autoimmune disease which choline receptor antibody mediates, cell immunity depends on and addiment participates.

The researchers found a new drug, called AEW-541, that blocks the receptor.

And DNA tests showed that the heavier drinkers had a particular variant of a dopamine receptor called DRD4.

Ambrisentan is a selective endothelin receptor antagonist for the treatment of pulmonary arterial hypertension with oral administration.

Although scientists have made progress in diagnosing cell receptor diseases, they have not yet found a way to cure them.

We also found positive correlated up regulation in the gene expression in A and its receptor in cardiovascular system.

Epidermal growth factor receptor and its signal transduction pathway in tumor targeting therapy with Chinese and Western medicines.

introduced several active areas of receptor modeling studies and put forward the major research projects to be launched now.

Folate receptor is deemed to be a preferable tumor marker. It is developed as marker of clinic diagnosis tumor at present.

substance P and substance P receptor in normal skin of each group had no significant differences in content.

Studies have found that EPO receptor is widely distributed in a variety of non-hematopoietic tissue, including myocardial tissue.

However, such methods were limited by the weather and the need for an uninterrupted line of sight between receptor points.

Objective To explore the correlation between lymph node metastasis and expression of VEGFC and its receptor (KDR) in colorectal carcinoma.

Androgen insensitivity is an X-linked disorder of male sexual differentiation resulting from a defective androgen receptor.

Aberrant ErbB receptor signals usually contribute to the progression and development of a number of human malignant tumors.

As a super-family of membrane receptor, G protein play various functions in the body.

These lines of evidence implicate a role of this receptor as an important target for antipsychotic drugs.

Based on these results, Dr. Thornton and his colleagues concluded that the evolution of the receptor unfolded in two chapters.

No change in the mRNA levels of these receptor subtypes was observed on the contralateral side.

Study on the relationship between abnormal endometrorrhagia and estrogen, progestogen level and its receptor.

Study of the Scavenger receptor in Smooth Muscle Cells and Pathogenesis of Lipid Collecting .

Objective: To investigate the existence of alternatively spliced variants of constitutive androstane receptor(CAR) in liver of mouse.

The sweet receptor is actually made up of two coupled proteins generated by two separate genes: known as Tas1r2 and Tas1r3.

Endocrine therapy with certain effect is an important part of combined therapy for hormone receptor-positive breast cancer.

Of 72 types of odour receptor on its antennae, at least 27 are tuned to detect chemicals found in perspiration.

Antiestrogens have been proven to be highly effective in the treatment of estrogen receptor-dependent breast cancer.

Raloxifene, a selective estrogen receptor modulator, is approved for the prevention and treatment of postmenopausal osteoporosis.

The molecular targeted drugs include epidermal growth factor receptor(EGFR) inhibitors, angiogenesis inhibitors and apoptosis promoters.

Molecular docking is to find the lowest energy conformation by the combination of the ligand and the receptor in their active area.

ManyNMDA receptor antagonists had been demonstrated to regulate morphine tolerance development.

When Dr. Thornton tried to return the receptor to its original form, these twists and tails got in the way.

Dr Munger, though, found that both GLP-1 and the receptor molecule that picks it up and thus allows it to act are found in taste buds too.

It is an ideal NMDA receptor imaging agent to have the character of specific binding and targeting to NMDA receptor.

Conclusion the central administration EM to enhance gastric motility may be mediated by the central motilin receptor.

The formalin-fixed, paraffin-embedded specimens with immunohistochemical staining for androgen receptor expression were surveyed.

What are the functions of the pre-BCR and pre-TCR in lymphocyte differentiation and antigen-receptor allelic exclusion?

In the normal brain and the body of some organs, the existence of endogenous opioid peptides and opioid receptor.

As the name implies, it is related to Toll, a receptor involved in pathogen recognition in the fly Drosophila melanogaster.

Experimental results show that the relative receptor transgenic tobacco resistant to salt has higher drought resistance capability.

Dr. Thornton reasoned that if he carried out the reverse operation, he could turn a new glucocorticoid receptor into an ancestral one.

Thus a receptor may be a protein, enzyme, membrane channel, or a region of a foreign pathogen.

Tyrosine kinases from the vascular endothelial growth factor and epidermal growth factor receptor families are the most pursued targets.

Recently, many progresses have been received in the regulation of membrane receptor signaling and transcription in the activation of HSC.

Baculoviruses enter mammalian liver cells by an unspecific endosomal uptake rather than by receptor-mediated means (3, 23).

H2 receptors has its own bionomics. The application of its receptor antagonist has potential value in therapy of colon cancer.

The receptor antagonist can be used to inhibit the internalization of the G protein-coupled receptor combing with PS1.

Another group of scientists who were similarly on the trail of a sour-taste receptor also hit upon PKD2L1 as a candidate.

We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.

Objective To investigate the relationship of epidermal growth factor (EGF) and its receptor(EGFR) with fetal birth weight.

Continuous erythropoietin receptor activator(CERA) is a third-generation erythropoiesis-stimulating agents(ESA).

What are - this understanding of receptor-ligand interactions has been really the biological basis of much of the pharmaceutical industry.

Sequences encoding nuclear receptor (NR) transcription factors furnish one striking example of this.

The mutant receptor appears to have evolved long ago and to be widely dispersed.

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily.

Researchers believe the receptor is part of a biochemical pathway involving many genes , defects in any of which may lead to the disease .

Background: As a powerful progesterone receptor antagonist, mifepristone has been widely applied in the termination of pregnancy.

The receptor proteins for lipid-soluble hormones (steroid hormones and thyroid hormones) are located within the target cell.

Abstract: Objective To determine the role of epidermal growth factor receptor (EGFR) signaling in bone development in mice.

it ' s a very , very important study addressing the issue of the effectiveness of angiotensin receptor blockers.

This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders.

Clinicopathologic Significance of the Mutations of the Epidermal Growth Factor Receptor Gene in Patients with Non-Small Cell Lung Cancer.

To determine the role of epidermal growth factor receptor (EGFR) signaling in endochondral ossification.

Cellular Vesicle Action The top images represent the signals sent to the computer by the vesicle (L) and the receptor cell (R).

Experiments are now under way in Debs's lab to try to establish how masking the receptor disrupts tumour growth signals.

The positive rate of T-cell receptor gene rearrangement was 81. 3%, and was independent of the histological features.

Methods We examined thirteen cases of syringoma using immunohistochemical staining for estrogen receptor(ER) and progesterone receptor(PR).

Select herbal therapies, as well as selective oestrogen receptor modulators, are also considered.

The technique was found to be a better prognostic tool than conventional visual analysis of receptor density.

OBJECTIVE: To observe the morphologic characteristics of the receptor pathway via the lumbar intervertebral disc.

Objective To detect the expression of atrial natriuretic peptide (ANP) and its receptor (NPR-A) in the developing rat cochlea.

abstract: Objective To observe the efficacy of treatment of leukotriene receptor antagonist montelukast to children allergic purpura.

That suggested that if the receptor is not active, the monocytes will not be released.

Prof Robert Thimme: For HCV patients we have two distinct populations which are either co expressing the inhibitor receptor or not.

In vivo, BPA appears to have greater activity than is suggested by its estrogen receptor (ER) binding affinity.

The prognostic significance of cortisol that may also bind and activate the mineralocorticoid receptor in chronic heart failure is unknown.

The mechanism of IR may be the combined defects of insulin biological effects at pre-receptor, receptor and post-receptor levels.

The C. elegans genome had just been decoded, and Dr. Bargmann was able to identify the worm's odorant receptor genes.

Objective To investigate the nursing experience of early diabetic nephropathy by treating with aldosterone receptor antagonist.

To determine the role of epidermal growth factor receptor signaling in endochondral ossification.

Tumors can use the machinery of this receptor to stimulate the unregulated growth and proliferation of cancer cells.

It can produce a receptor, activation of the immune system to resist the invasion of pathogens.

Study of CCK receptor polymorphism may reveal some universal rules in GPCR superfamily.

Most of the volatile and intravenous anesthetics potentiate the function of GABAA receptor to different extent.

CHANGES OF MELATONIN AND ITS RECEPTOR IN ISCHEMIC CEREBRAL APOPLEXY RATS AND EFFECT OF PRETREATMENT WITH MELATONIN.

The component of basement membrane plays important role in regulating tumor metastasis by interacting with cell surface receptor integrins.

The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

The Sympathomimetic Actions of l-Ephedrine and d-Pseudoephedrine: Direct Receptor Activation or Norepinephrine Release?

Antibodies that bind specifically to receptor for advanced glycation end products (RAGE) and RAGE-binding fragments thereof are disclosed.

The team plans to develop an antibody drug to block the receptor from interacting with the T-cells and slow down the disease.

Hemagglutinin specificity binding with glycan chains receptor on cell surface determines the host range of influenza viruses.

Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer.

Researchers have worked out how a mammal's tongue detects sour tastes: it's all down to a single, specialized receptor, they say.

Dynamics of respiration pathway in transgenic salt-tolerant wheat and its receptor under salt stress.

Recently it has been suggested a potential association ABD and VD receptor polymorphism, or malnutrition state.

Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway.

Genomic drift also generates a substantial amount of copy-number variation in chemosensory receptor genes within species.

Objective: To observe the expression, distribution and development of leptin and its receptor in fetal submandibular glands.

In humans they have identified, so far, about 17 different lengths of [the vasopressin receptor gene].

Tumor receptor imaging and receptor targeted radiotherapy have been extensive studied and have high value in cancer diagnosis and therapy.

This suggests the involvement of immunologic mechanism by receptor antibody in the pathogenesis of cardiovascular diseases.

To model thresholds we assumed that discrimination was mediated by opponent mechanisms whose performance was limited by receptor noise.

This review focuses on the research progress in glucocorticoid receptor during stress-induced multiple organ dysfunction.

The pheromone receptor of Auricularia auricula was similar to counterparts of tetrapolar basidiomycetes on the basis of BLAST results.

At the top of each Eimer's organ, however, lies a receptor unique to moles.

Due to chirality of odor receptors in the nose the R- carvone and S- carvone fit into different receptor sites, hence different odor.

Objective To explore the activity change of the dopamine D2 receptor and its rule during the process of Parkinson's disease ( PD ).

The role of leukotriene receptor antagonists in the treatment of persistent asthma is in evolution.

Objective To assess the effectiveness and safety of angiotensin II receptor antagonists(ARB) in treatment of portal hypertension.

Whether T cells continue to multiply depends on the action of sensitive receptor proteins on their surfaces.

And the bacteria also have a receptor on their cell surface that fits like a lock and key with that molecule.

Earlier studies have suggested that each protein from the parasite attaches to only one specific protein, a receptor, in the placenta.

Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist.

In the first, the receptor acquired the seven key mutations that made it sensitive to cortisol and not to other hormones.

The control of parathyroid hormone (PTH) secretion is strictly regulated by the parathyroid Ca receptor (CaR).

through endocytosis , will be transferred to the lysosomes in the receptor degradation, namely receptor down-conditioning.

In two of the 1918 isolates, this receptor-binding site differs from an avian form by only one amino acid building block.

The development on the receptor modeling used to perform source apportionment of atmospheric particulates in ambient air was introduced.

The process of insulin metabolism starts with binding of insulin to its receptor on the cell surface.

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers .

Concern has been raised that phytoestrogens may interfere with selective estrogen receptor modulators and aromatase inhibitors.

Conclusion The expression of CX43 mRNA in hippocampus can be decreased by transferring GABA receptor gene into hypothalamus.

After bound by the receptor, diphtheria toxin (DT) enter endosomes by receptor mediated endocytosis.

The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro.

The study focused on different versions of a receptor for the neurotransmitter dopamine, which controls feelings of pleasure.

The present invention is directed to compounds of Formula (I), or salt thereof, which are modulators of the glucocorticoid receptor.

This indicated that, donor DNA fragment had inserted into receptor through pollen tube, and affected the expression of genes in receptors.

Direct and indirect receptor-independent G-protein activation by cationic-amphiphilic substances.

She linked this difference in behavior to the switch of a single amino acid unit in a protein called npr-1 (for neuropeptide Y receptor-1).

OBJECTIVE: To observe the receptor pathway of lumbar facet joint and lamina muscle attachment points morphologically in the rabbits.

At the receptor level, it is a chemical entity that opposes the receptor-associated responses normally induced by another bioactive agent.

Objective To explore the expression change of protein and mRNA of EGFR(epidermal growth factor receptor)in RAU(recurrent aphthous ulcer).

Scientists have identified the receptor used by a virus that plagued chimpanzees' ancestors.

Comparisons with the role of the pre-T-cell receptor (pre-TCR) in T-cell development raise provocative questions.

Objective To explore the relationship between estrogen receptor (ER) or progesterone receptor (PR) and epilepsy.

The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease.

RESULTS& CONCLUSION: Partial dopamine receptor agonist is effective and safe for schizophrenia .

Analysis of receptor-ligand interactions in vivo is key to biology but poses a considerable challenge to quantitative microscopy.

OBJECTIVE: To evaluate the clinical application of leukotriene receptor antagonists.

Each has receptor molecules on its surface that Bind to a specific antigen.

Tumor receptor imaging with isotope labeled octreotide is a suitable noninvasive technique int. . .

A mutation in a glutamate receptor gene common to both the fruit fly and humans has the ability to disrupt that regulatory mechanism.

Its function main dependence main center and the circumference chemical receptor, the circumference pulls opens the receptor.

The molecule blocked a gene that codes for a receptor for GABA, a brain signaling molecule.

They also speculate that the variable effects of beta antagonists may be caused by genetic polymorphisms in the beta-adrenergic receptor.

Although the sulfated xenobiotics bind poorly to the ER, both stimulated the growth of receptor-positive breast tumor cells.

Anakinra, a recombinant human IL-1 receptor antagonist, may be effective in treatment-resistant ankylosing spondylitis.

Sodium phenobarbital caused marked rises in PT by suppressing GABA uptake, activating GABA receptor and GABA-mimetic action.

Tamoxifen antagonized effect of estradiol, suggested that estradiol inhibited neointimal proliferation by estrogen receptor.

Likewise, increased XOR levels hiked activity of the PPAR-gamma receptor in both fat cells and fat cell precursors.

Beyond this distance, some of the detail in the picture can no longer be resolved by the conical receptor cells in the retina of the eye.

Selective estrogen-receptor modulators (eg, raloxifene) may reduce risk of developing breast cancer.

Transient receptor potential A1 (TRPA1) is a cold sensitive cation channel, which could also be activated by various pungent compounds.

Studies have shown that prolactin gene and prolactin receptor gene mutation would give rise to animal breeding dysfunction.

Glucocorticoid receptor activation in the fetal lung triggers maturation necessary for extra-uterine life.

Our results establish the first structural model of a plant hormone receptor.

And the Dundee team has found that these neurosteroids operate through the same GABA-A receptor as synthetic anesthetics do.

A set of changes in the mongoose's receptor makes it resemble the cobra's own resistant receptor.

ObjectiveTo explore the feasibility of gastrin receptor antagonist application in the management of pancreatic adenocarcinoma.

Conclusion: We suggested that highly efficient gene expression systems and receptor cells. . .

Studying the effects of increasing the estrogen receptor in other brain regions may shed additional light on memory processes.

The researchers, therefore, undertook an in-depth study aimed at determining if FSH receptor was present in the blood vessels of tumours.

This receptor is broadly distributed in carcinomas, sarcomas , leukemias, and lymphomas.

Hantavirus enters into cells by clathrin-dependent receptor-mediated endocytosis .

C. Raloxifene (Evista) is a selective estrogen receptor modulator. It is available for prevention and treatment of osteoporosis.

The author makes a summary including membrane estrogen receptor-mediated non-genomic effects and the signal pathways involved.

Researchers previously knew that the tongue carries a receptor called TAS2R, which comes in several different forms.

The central curve, labeled binding, depicts the occupation of receptor by increasing concentrations of drug.

Till now, ET-1 receptor antagonist is the most promising drug that can be used for pulmonary hypertension.

The increased risks were mainly confined to women with hormone-receptor-positive tumors and tumors located in the breast lobules.

In addition, androgen can induce the injury of skeletal muscle through a receptor independent mechanism.

Objective To investigate the influence of genotypes of calcitonin receptor on bone mineral density in male subjects.

Soluble T-cell receptor compositions that bind to HLA class I-restricted of HIV and HCV pathogens were identified and constructed.

Scientists have identified a receptor in mouse cells that controls how fat is used in the body.

Accumulating evidence indicates that Notch is a candidate receptor that might mediate these signals.

The KRAS proto-oncogene product lies downstream of EGFR, and the mutation frees the receptor from normal regulation in cell-growth control.

The diagnosis of restless legs in based on its characteristic clinical presentation. Levodopa and dopamine receptor agonist were effective.

Thus, we concluded that the steric hindrance of C-terminus might play an important role in opioid receptor affinity.

Surprisingly, in view of the working assumption about humans, the type of testosterone receptor that a bird had proved to be irrelevant.

Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.

Objective To explore the relationship between laminin (LN), laminin receptor (LN-R) and the invasion of trophoblastic cells.

The scientists found that nicotine administration to mice induces the expression of a gene called type 2 ryanodine receptor (RyR2).

Women with oestrogen receptor negative disease have fewer treatment options and new ways to tackle it are urgently needed.

In general, blood vessels which express FSH receptor are found at the periphery of the tumour.