rapamycin

Rapamycin is a critical-dose drug requiring at least monthly monitoring of drug concentrations in the blood.

Future studies on rapamycin and mTOR will work backwards from the general effect to specific mechanisms, said Harrison.

the effects of rapamycin as a pharmacological preconditioning agent during IR on the severity of injury in vitro have been studied.

The fact that rapamycin is already clinically approved for other uses will facilitate future clinical trials of the drug.

Previous research on rapamycin has hinted that it may have the power to extend human lifespan by more than a decade.

However, because rapamycin depresses the immune system, it would have serious side effects for people with Parkinson's.

Pharmaceutical companies would also be wise to hunt for drugs that act on the same biological pathway as rapamycin.

Figure 1: A plaque on Easter Island commemorating the discovery of a bacterium producing rapamycin, a potent immunosuppressant.

But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species. "

Healthy ageing will also be the metric by which medicines like rapamycin are tested against in humans, says Kaeberlein.

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation.

Dr Harrison and his colleagues picked a different molecule that has been seen to work on invertebrates: rapamycin.

A novel, simple and cost effective assay for monitoring blood levels of rapamycin (sirolimus) and rapamycin analogues was developed.

But rapamycin, a fungus-fighting bacterial secretion originally discovered in the soil of Easter Island, showed a marked effect.

Rapamycin is a bacterial product originally found in a soil sample from Easter Island.

It's unclear whether these problems would counteract any longevity benefit that rapamycin might provide in humans.

The most commonly used anti-proliferative drugs are paclitaxel and rapamycin, and their derivatives.

Rapamycin suppresses the immune system and carries strong warnings about the resulting risk of infections and death.

Rapamycin is known as a kind of macrolide antibiotics.

That ability also made rapamycin a candidate for research into the mechanisms of aging.

Earlier human trials have shown, however, that rapamycin can have serious side effects.

Bency: In contrast to control group, however, only those groups that rapamycin was given before ischemia can reduce infarct area.

Methods Rapamycin was selected to replace previous basic immunosuppressive drugs for the treatment of 7 cases resistant extensive cGVHD.

More than 1, 900 mice, their total genetic variation roughly comparable to that found in humans, were fed rapamycin.

Several researchers, and the editorial in Nature, cautioned people about taking rapamycin, which is available only by prescription.

The drug, called rapamycin, was originally found in bacteria from Easter Island.

Conclusion Regimen and dosage of rapamycin in this study were safe to patients and very good response is observed.

Rapamycin is not perfect, however.

When tested on nine-month-old mice, rapamycin had little effect.

This drug, rapamycin, was originally discovered in the 1970s in soil from Easter Island.

Conclution: Rapamycin inhibited the proliferation of leukemia HL-60 cells dependent on density and time.

Methods: The inhibitation of HL-60 cells by Rapamycin was measured by MTT assay.

The macrolide rapamycin is used clinically to treat graft rejection and restenosis.

That is not to recommend people take doses of rapamycin.

Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: A randomized comparison of a simple versus complex st

Clinical result of Rapamycin eluting stent implanting in the patients with coronary heart disease combined with diabetes

Experimental studies of rapamycin eye drops on the prevention of penetrating keratoplasty rejection in a rat model

Sustained rapamycin drug delivery system in prevention of high risk corneal allograft rejection and neovascularization in rabbits

A Randomized Comparison Between Paclitaxel-Eluting Stents and Rapamycin-Eluting Stents for Patients With Coronary Artery Diseases

Experimental study on rapamycin-batroxobin eluting stent and its prevention of coronary restenosis after angiophaty

Rapamycin inhibits the pathogenesis of posterior capsule opacification: experimental study on rabbit

The inhibiting effects of rapamycin on signal transudation in vascular smooth muscle cell induced by oxidized low density lipoprotein

Effects of Rapamycin Eluting Stents on Blood Tissue Factor and Tissue Factor Pathway Inhibitor in Patients With Acute Coronary Syndromes

Immunosuppressive effect of rapamycin on immunological rejection after high-risk corneal transplantation in rats

The expression of mammalian target of rapamycin and its substrates in autogenous vein graft in rats

Therapeutic window of whole-blood rapamycin concentration in recipients of renal transplantation

Efficacy of Rapamycin Eluting Stent and Paclitaxel Eluting Stent in Patients with Coronary Artery Disease and Diabetes

Clinical Benefits of Rapamycin-Eluting Stent Implantation in Patients With Acute Coronary Syndromes

Effect of rapamycin and dexamethasone on differentiation and maturation of murine bone marrow-derived dendritic cells

Inhibition of growth and metastasis of hepatocellular carcinoma by rapamycin: experiment with mice

Effect of locally administered rapamycin and cyclosporin A on penetrating keratoplasty rejection rat model

Therapeutic effect of rapamycin in the treatment of malignancies in recipients after kidney transplantation

Local Application of Rapamycin Inhibiting Restenosis in Experimental Vein Graft

Research advance on rapamycin-eluting stent in preventing coronary artery restenosis

The Clinical Application of Rapamycin Eluting Stent in Elderly Patients with Coronary Heart Disease

Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia Post Balloon Injury in Rat

Effects of rapamycin- treated HSP60- pulsed dendritic cells on the progression of the atherosclerotic plaque in mice

The experimental study on the effects of rapamycin and statin on chronic transplant vasculopathy

Experimental study on the effects of rapamycin in prevention of rat corneal allograft rejection

Clinical Research of Rapamycin-Eluting Stent in Treatment of Multi-Vessel Coronary Disease

Effect of combination of curcumin and rapamycin on proliferation of rat glomerular mesangial cells

Effects of Rapamycin-Eluting Stent on Level of Inflammatory Factors in Coronary Heart Disease Patients After Angioplasty

Local application of rapamycin inhibits neointimal hyperplasia in experimental vein grafts

Screening of Rapamycin producing strain by high energy electrons mutation

Effects of rapamycin on regeneration of cultured rabbit lens epithelial cells

Clinic application of rapamycin-eluting stent for coronary heart disease

Effect of Biodegradable Rapamycin-Eluting Stent on Neointimal Proliferation in Porcine Coronary Artery Model

Rapamycin inhibited the growth of hepatocellular carcinoma in nude mice

The role of mammalian target of rapamycin in the pathogenesis of diabetic nephropathy

Prolonged survival of renal allografts with domestic rapamycin in rats

low-dose and high dose of rapamycin could not inhibit the growth of planted subcutaneous glioma in nude mouse;

Domestic-made rapamycin-eluting stent in left main coronary artery lesion

Local applied slow-releasing rapamycin inhibits neointima hyperplasia in vein graft

Effect of rapamycin on serum lipids in patients with renal transplantation

Role of Mitochondria in Apoptosis Induced by Rapamycin of Hepatocellular Carcinoma Bel-7402 Cells

One year effect of rapamycin eluting stent in patients with coronary heart disease

Effect of rapamycin on tumor growth in rats with liver transplantation

The Studies of Antitumor Effect of Rapamycin on Human Hepatocellular Carcinoma BEL-7402 Cells in vitro

Effect of rapamycin on expression of origin recognition complex 1 mRNA in vascular smooth muscle cells

The effect of antisense mammalian target of rapamycin gene transfection on neointimal formation in vein graft in rats