microbicide

He said the current oral use of tenofovir is highly effective and safe, and that tenofovir microbicide differs from previous microbicides.

"But I think it's safe to say that Carraguard as a sole microbicide agent does not work, " he told SciDev. Net.

Finding new drugs like a microbicide often can be a process of trial and error, and requires scientifically rigorous trials, Piot said.

Clinical trials are ongoing for at least a dozen different vaginal microbicides, according to the Alliance for Microbicide Development.

She said that research is ongoing into microbicide vaginal gels for prevention of infection by HIV.

Tenofovir gel is a third generation microbicide and is unique in that it works within cells to stop HIV from replicating.

Second, the microbicide would prevent any irus that escaped from attaching to a woman's cells, the way the irus starts to infect.

A vaginal microbicide (none exists, but at least one trial has gone well) could protect women.

The problem is that to get a solid microbicide to all the right places, it is easiest if it starts off runny.

"I feel a huge sense of urgency to make sure a pill or microbicide is developed as soon as possible, " he says.

The Lancet published the results of a failed trial of a vaginal microbicide gel to protect women from HIV infection last week (6 December).

Third, for any virus that did enter cells, the microbicide would block an enzyme, reverse transcriptase, that the virus needs to replicate.

The addition of an antiretroviral drug to the microbicide should also prevent the HIV from multiplying.

Plus, in order for men to benefit from the microbicide, it would have to protect them from an HIV-positive woman, she adds.

Health experts say the vaccine and microbicide trials have failed to prevent AIDS research needs to focus on anti-retroviral drugs.

Data from these clinical trials will be indispensable to the researchers and developers of emerging and future microbicide candidates.

Microbicide was a major approach to preventing sexual transmission of HIV.

Some opposed tenofovir's use in a microbicide because they worried that it would encourage the emergence of such resistance.

One of the major announcements expected at the 18th International AIDS conference is about a microbicide gel called CAPRISA 004.

Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed.

This review is to briefly introduce the mechanism of action and current status of some microbicide candidates.

Microbicide experts took issue with the model's real-world relevance.

The majority of microbicide research thus far has focused on products to prevent HIV during vaginal sex.

Additionally, the microbicide was used in only 42 per cent of sex acts.

Dr. Sheena McCormack, a British microbicide researcher, recalled penicillin tests of 70 years ago.

They envisaged a microbicide-containing lining for the vaginal tract that is a squishy solid rather than a liquid.

A microbicide that works against HIV?

Earlier this year a clinical trial showed for the first time that a microbicide gel can help prevention of HIV.

As a result, the microbicide re-liquefies.

Manufacture and Properties of the Microbicide Oxygen and Carbon Dioxide Absorbent

High Effective Compound Microbicide Inhibits Stink of Garbage Disposal Plant